摘要
以廉价易得、商品化的铁粉为反应促进剂,研究了溴代硝基甲烷与各种醛的Henry型反应,高效地合成了2-硝基-1-醇.该反应在PbCl_(2)和四丁基硫酸氢铵(TBAHS)存在下有效地进行,以中等至良好的产率得到目标产物,并且该反应具有广泛的官能团耐受性.
The Henry-type reaction of bromonitromethane with various aldehydes for the efficient synthesis of 2-nitro-alkan-1-ols by using inexpensive and commercial iron powder as reaction mediator was developed.The reaction proceeded efficiently in the presence of PbCl_(2)and tetrabutylammonium hydrogen sulfate(TBAHS)to produce the desired products in moderate to good yield with wide functional group tolerance.
作者
张斯旋
李祥瑞
李文欣
饶卫东
葛丹华
沈志良
褚雪强
Zhang Sixuan;Li Xiangrui;Li Wenxin;Rao Weidong;Ge Danhua;Shen Zhiliang;Chu Xueqiang(Chemical Experiment Teaching Center,Institute of Advanced Synthesis,School of Chemistry and Molecular Engineering,Nanjing Tech University,Nanjing 211816;Jiangsu Key Laboratory of Biomass-based Green Fuels and Chemicals,College of Chemical Engineering,Nanjing Forestry University,Nanjing 21003)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2022年第1期235-241,共7页
Chinese Journal of Organic Chemistry
基金
南京工业大学科研启动基金(Nos.39837118,39837146)
国家自然科学基金(No.22001121)
江苏省自然科学基金(No.BK20180690)资助项目.
