误服西布曲明致幼儿5-羟色胺综合征

Serotonin syndrome caused by mistaken use of sibutramine in a child

1例2岁4个月女童误服其母亲减肥保健品约30 min后出现呕吐、频繁抽搐、发热、失眠、烦躁、行为异常、肢体摆动、心动过速、呼吸急促等症状,血常规及血生化检查无明显异常,给予洗胃、降颅压及对症治疗,11 d后患儿症状基本消失。其母减肥保健品鉴定结果显示其主要成分为西布曲明。患儿被确诊为西布曲明中毒导致的5-羟色胺综合征。

A 2‑year and 4‑month‑old girl had vomiting,frequent convulsions,fever,insomnia,irritability,abnormal behavior,limb swing,tachycardia,shortness of breath,etc.after mistaken use of her mother′s weight loss healthcare products for about half an hour.Blood routine and blood biochemical examination showed no obvious abnormalities.Gastric lavage,intracranial pressure reduction,and symptomatic treatments were given,and 11 days later,her symptoms basically disappeared.The identification results of the weight loss healthcare products showed that the main component was sibutramine.Then serotonin syndrome caused by sibutramine poisoning was diagnosed.