稀释碘伏液间断灌洗治疗胰瘘的临床价值

Clinical value of intermittent flushing with diluted iodine solution treated pancreatic fistula

目的探究稀释碘伏液间断灌洗并负压引流治疗胰瘘的临床疗效。方法纳入2016年1月-2020年12月在兰州大学第一医院普外科收治的胰瘘患者49例,随机分为治疗组25例,在常规治疗的基础上应用稀释碘伏液间断冲洗加负压引流;对照组24例,常规腹腔置管引流治疗。分析组间胰瘘患者的疗效、血清肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、C-反应蛋白(CRP)、D-二聚体及凝血情况。结果治疗组置管时间、腹腔感染发生率明显低于对照组(P<0.05);治疗组TNF-α、IL-1β、CRP血清下降水平低于对照组(P<0.05)。结论稀释碘伏液间断冲洗并负压引流可减低炎性细胞因子从而提高胰瘘的临床疗效,缩短患者的治疗时间。

Objective To explore the effect of intermittent flushing with dilute iodine water combined with negative pressure drainage to treat pancreatic fistula.Methods The study included 49 patients with pancreatic fistula admitted to Department of General Surgery,the First Hospital of Lanzhou University from January2016 to December 2020.Using the random method,25 patients were treated with dilute iodine water intermittent flushing combined with negative pressure drainage as the treatment group,and 24 patients with traditional drainage scheme as the control group.Differences were observed of the two groups in the curative effect,and the tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),C-reactive protein(CRP),D-dimer and blood coagulation also were observed.Results The duration of catheter drainage and incidence of abdominal infection in the observed group were significantly lower than those in the control group,with statistically significant(P<0.05).The serum levels of TNF-α,IL-1βand CRP in the observed group were lower than those in the control group(P<0.05).Conclusion Intermittent flushing with dilute iodine water combined with negative pressure drainage for treatment could significantly reduce inflammatory cytokines so as to improve the clinical efficacy of pancreatic fistula and shorten the treatment time of patients with pancreatic fistula.