2004-2018年甘肃省大骨节病流行趋势分析

Epidemic trend of Kaschin-Beck Disease in Gansu Province from 2004 to 2018

目的掌握甘肃省大骨节病病情变化趋势,为大骨节病防治提供科学依据。方法以甘肃省37个大骨节病病区县(区)选择监测点7~12或7~16岁儿童作为对象,收集其2004-2018年大骨节病临床及X线监测结果,分析大骨节病流行趋势。结果2004-2018年,甘肃省临床累计检查儿童97190人,X线累计检查94180人,检出临床阳性病例428人,检出率为0.44%;X线阳性病例649人,检出率为0.69%;干骺端阳性病例435人,检出率为0.46%;骨端阳性病例214人,检出率为0.23%。临床阳性检出率2004年最高(7.17%,58/809),其次为2007年(4.60%,51/1109)和2005年(4.48%,187/4173),其余年份检出率均<3%;X线阳性检出率2004年最高(9.59%,58/605),其次为2005年(5.10%,213/4173)、2008年(3.66%,45/1228)和2006年(3.04%,125/4107),其余年份检出率均<3%。结论甘肃省儿童大骨节病临床阳性检出率和X线阳性检出率均为迅速下降后维持低位波动,综合防治措施效果显著。

Objective To master the epidemic trend of Kashin-Beck disease(KBD)in Gansu Province and provide a scientific basis for prevention and treatment of KBD.Methods All children aged 7-12 or 16 years old were selected as the survey subjects in 37 KBD districts and counties in Gansu Province,clinical and X-ray monitoring results of KBD in children from 2004 to 2018 were collected to analyze the epidemic trend of the disease.Results From 2004 to 2018,a total of 97190 children were examined clinically and 94180 X-ray films were taken in Gansu Province.Four hundred and twenty-eight clinical positive cases were detected,with a detection rate of 0.44%.There were 649 X-ray positive cases,and the detection rate was 0.69%.There were 435 metaphyseal positive cases,the detection rate was 0.46%.There were 214 positive cases of bone end,and the detection rate was 0.23%.The clinical positive rate was the highest(7.17%,58/809)in 2004,followed by 2007(4.60%,51/1109)and 2005(4.48%,187/4173),and the positive rate in other years was less than 3%.The positive rate of X-ray was the highest(9.59%,58/605)in 2004,followed by 2005(5.10%,213/4173),2008(3.66%,45/1228)and 2006(3.04%,125/4107),the positive rate of other years was less than 3%.Conclusions The clinical positive rate and X-ray positive rate of KBD in children in Gansu Province are decreased rapidly and then maintain a low fluctuation.The effect of comprehensive prevention and control measures is remarkable.