摘要
N-甲基-D-天冬氨酸受体(NMDAR)是重要的离子型谷氨酸受体,具有配体及电压双重门控离子通道特性,组成及功能复杂,分布广泛,在多种疾病或应激状态的病理生理进程中起着关键作用。其可通过线粒体及内质网损伤、活性氧与过氧亚硝酸盐生成、丝裂原活化蛋白激酶及钙蛋白酶激活等不同途径介导细胞凋亡。本文就NMDAR的结构分布、生物特性及其介导的信号通路在细胞凋亡中作用机制等方面进行综述。
N-methyl-D-aspartate receptor(NMDAR),an important ionic glutamate receptor and a ligand and voltage-gated ion channel characterized by complex composition and functions and wide distribution,plays a key role in the pathological and physiological process of diseases or stress states.NMDAR can mediate apoptosis through different pathways such as mitochondrial and endoplasmic reticulum damage,production of reactive oxygen species and peroxynitrite,and activation of mitogen-activated protein kinase and calpain.This paper reviews the structure,distribution,and biological characteristics of NMDAR and the mechanisms of NMDAR-mediated apoptosis.
作者
韩宜晓
侯雅竹
闫海峰
王帅
王贤良
毛静远
HAN Yixiao;HOU Yazhu;YAN Haifeng;WANG Shuai;WANG Xianliang;MAO Jingyuan(Department of Cardiology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2022年第1期149-157,共9页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金(81904150)
天津市科技计划项目(15ZXLCSY00020)
教育部“创新团队发展计划”(IRT_16R54)
天津市中医药重点领域科研项目(2017002)
天津市研究生科研创新项目(2019YJSB142)
天津中医药大学研究生科研创新项目(YJSKC-20191018)。
