摘要
半乳糖凝集素-3(galectin-3,gal-3)与脑卒中的关系近年来被越来越多的研究者关注。该综述通过从脑卒中后gal-3在颅内炎症反应中的作用到参与颅内组织重塑的过程来阐述其对脑卒中病理生理变化产生的影响。同时,回顾了gal-3与脑卒中发病率及预后之间的关系,进一步分析了gal-3对临床的指导意义,提出既往研究的不足、现有矛盾及未来探索方向。该综述旨在对gal-3在脑卒中发生后的病理生理学作用、gal-3与脑卒中发病和预后之间相关性的研究进展进行介绍及分析。
The relationship between galectin-3(gal-3)and stroke has received increasing attention from researchers in recent years.The review discusses the effects of gal-3 on the pathophysiological changes of stroke from its role in the intracranial inflammatory re⁃sponse to the process of intracranial tissue remodeling after stroke.Meanwhile,the relationship between gal-3 and the incidence and prognosis of stroke was reviewed,the clinical guidance of gal-3 was further analyzed,and the deficiencies of previous studies,existing contradictions,and future exploration directions were proposed.This review aims to introduce and analyze the pathophysiological role of gal-3 after stroke and the research progress on the correlation between gal-3 and stroke incidence and prognosis.
作者
张永康
韩燕
ZHANG Yongkang;HAN Yan(Department of Vascular Disease,Shanghai Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200082,China;Department of Neurology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
出处
《安徽医药》
CAS
2022年第3期434-438,共5页
Anhui Medical and Pharmaceutical Journal
基金
上海市中医药三年行动计划项目[ZY(2018-2020)-CCCX-2004-10]。
