铁死亡抑制蛋白1:心肌再灌注损伤的潜在治疗靶点

Ferroptosis suppressor protein 1:potential therapeutic targets for myocardial reperfusion injury

铁死亡抑制蛋白1(ferroptosis suppressor protein 1,FSP1)是新近发现的铁死亡抑制因子,又是一种具有烟酰胺腺嘌呤二核苷酸磷酸(NADH)氧化还原酶特性的黄素蛋白,具有参与活性氧(reactive oxygen species,ROS)生成及促进线粒体电子传递等功能。研究表明FSP1与乳腺癌、类风湿性关节炎、重症胰腺炎、帕金森综合征等人类疾病相关,根据FSP1的功能特性,推测FSP1是未来心肌缺血再灌注损伤的潜在治疗靶点,本文对FSP1的功能特性及与心肌再灌注损伤的相关性进行总结,为未来疾病的治疗提供新的思路。

Ferroptosis suppressor protein 1(FSP1),a flavoprotein with an NADH/NAD oxidoreductase domain,which is involved in regulation of reactive oxygen species(ROS)and promotes mitochondrial electron transport,was recently confirmed to be a ferroptosis-resistant factor.Many studies have found that FSP1 plays a key role in many human diseases,such as breast cancer,rheumatoid arthritis,severe acute pancreatitis and Parkinson's syndrome.Based on the biological characteristics of FSP1,we speculate that FSP1 is a potential therapeutic target for myocardial reperfusion injury in the future.The relationship between FSP1 and myocardial reperfusion injury has been briefly described in this review,which provides a new target molecules for the treatment in the future.