复发性流产患者血清维生素D水平与NK细胞、淋巴细胞亚群的关系

Relationship between serum vitamin D level and natural killer cells,lymphocyte subsets in patients with recurrent spontaneous abortion

目的探讨复发性流产(RSA)患者血清维生素D水平与NK细胞、淋巴细胞亚群的关系。方法选取2019年1月至2021年6月就诊于本院的150例RSA患者作为研究对象,将血清25-(OH)D<50 nmol/L的110例患者作为观察组,血清25-(OH)D≥50 nmol/L的40例患者作为对照组。比较两组CD16^(+)CD56^(+)、CD3^(-)CD16^(+)CD56^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+),分析25-(OH)D水平与CD16^(+)CD56^(+)、CD3^(-)CD16^(+)CD56^(+)、CD4^(+)/CD8^(+)的相关性。结果观察组CD16^(+)CD56^(+)、CD3^(-)CD16^(+)CD56^(+)、CD4^(+)及CD4^(+)/CD8^(+)高于对照组(P<0.05)。RSA患者的25-(OH)D水平与CD16^(+)CD56^(+)、CD3^(-)CD16^(+)CD56^(+)、CD4^(+)/CD8^(+)呈负相关(P<0.05)。结论RSA患者血清维生素D水平与NK细胞及CD4^(+)/CD8^(+)呈负相关,维生素D水平下降可能会增加RSA的发生风险。

Objective To investigate the relationship between serum vitamin D level and natural killer cells,lymphocyte subsets in patients with recurrent spontaneous abortion(RSA).Methods A total of 150 RSA patients admitted in our hospital from January 2019 to June 2021 were selected as the study objects,110 patients with serum 25-(OH)D<50 nmol/L were selected as observation group,and 40 patients with serum 25-(OH)D≥50 nmol/L were selected as control group.The CD16^(+)CD56^(+),CD3^(-)CD16^(+)CD56^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)were compared between the two groups,and the correlation between 25-(OH)D level and CD16^(+)CD56^(+),CD3^(-)CD16^(+)CD56^(+),CD4^(+)/CD8^(+)were analyzed.Results The CD16^(+)CD56^(+),CD3^(-)CD16^(+)CD56^(+),CD4^(+)and CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05).The 25-(OH)D level of RSA patients was negatively correlated with CD16^(+)CD56^(+),CD3^(-)CD16^(+)CD56^(+)and CD4^(+)/CD8^(+)(P<0.05).Conclusion The serum vitamin D level in patients with RSA is negatively correlated with natural killer cells and CD4^(+)/CD8^(+),and the decrease of vitamin D level may increase the risk of RSA.