3D腹腔镜经口腔前庭入路甲状腺切除术治疗分化型甲状腺癌的临床效果

Clinical effect of 3D laparoscopic thyroidectomy via oral vestibular approach in the treatment of differentiated thyroid cancer

目的探讨3D腹腔镜经口腔前庭入路甲状腺切除术治疗分化型甲状腺癌的临床效果。方法按随机数字表法将2017年1月至2020年12月收治的98例分化型甲状腺癌患者分为对照组和观察组,各49例。对照组采取2D腹腔镜经口腔前庭入路甲状腺切除术,观察组采取3D腹腔镜经口腔前庭入路甲状腺切除术。比较两组的临床病情控制情况、疼痛程度、TNF-α、IL-6水平、外周血循环肿瘤细胞(CTC)计数及治疗满意度。结果术后1周,观察组的临床病情控制总有效率高于对照组(P<0.05)。观察组术后12、24、48、72 h的VAS评分均低于对照组(P<0.05)。观察组术后3 d的TNF-α、IL-6水平及CTC计数均低于对照组(P<0.05)。观察组的治疗满意度高于对照组,差异具有统计学意义(P<0.05)。结论采用3D腹腔镜经口腔前庭入路甲状腺切除术治疗分化型甲状腺癌,可有效控制病情,减轻疼痛,改善血液循环肿瘤细胞负荷,提高治疗满意度。

Objective To explore the clinical effect of 3D laparoscopic thyroidectomy via oral vestibular approach in the treatment of differentiated thyroid cancer.Methods Ninety-eight patients with differentiated thyroid cancer treated from January 2017 to December 2020 were divided into control group and observation group according to the random number table method,with 49 cases in each group.The control group received 2D laparoscopic thyroidectomy via oral vestibular approach,while the observation group received 3D laparoscopic thyroidectomy via oral vestibular approach.The clinical condition control,pain degree,TNF-α,IL-6 levels,peripheral blood circulation tumor cell(CTC)count and treatment satisfaction were compared between the two groups.Results At one week after operation,the total effective rate of clinical condition control in the observation group was higher than that in the control group(P<0.05).The VAS score at 12,24,48 and 72 h after operation of the observation group was lower than that of the control group(P<0.05).The levels of TNF-α,IL-6 and CTC count in the observation group were lower than those in the control group at 3 d after operation(P<0.05).The treatment satisfaction of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion 3D laparoscopic thyroidectomy via oral vestibular approach in the treatment of differentiated thyroid cancer can effectively control the condition,reduce pain,improve the tumor cell load in blood circulation,and increase treatment satisfaction.