度洛西汀联合曲唑酮治疗抑郁症患者的临床效果

Clinical effect of duloxetine combined with trazodone in the treatment of patients with depression

目的探讨度洛西汀联合曲唑酮治疗抑郁症患者的临床效果。方法选取2020年1月至2021年5月我院收治的120例抑郁症患者作为研究对象,根据治疗方案不同将其分为A组、B组、C组,每组40例。三组入院后均接受心理治疗,A组给予度洛西汀治疗,B组给予曲唑酮治疗,C组给予度洛西汀联合曲唑酮治疗。比较三组的抑郁情况、睡眠情况、社会支持水平、血清生化指标水平及临床疗效。结果治疗4、8周后,三组的HAMD、SDS评分比较,差异具有统计学意义(P<0.05);治疗4、8周后,A组、B组的HAMD、SDS评分高于C组,差异具有统计学意义(P<0.05)。治疗后,三组的ISI、PSQI、SSRS评分比较,差异具有统计学意义(P<0.05);治疗后,A组、B组的ISI、PSQI评分高于C组,SSRS评分低于C组,差异具有统计学意义(P<0.05)。治疗后,三组的BDNF、GDNF、5-HT、NSE、S-100B蛋白水平比较,差异具有统计学意义(P<0.05);治疗后,A组、B组的BDNF、GDNF、5-HT水平低于C组,NSE、S-100B蛋白水平高于C组,差异具有统计学意义(P<0.05)。A组、B组的治疗总有效率低于C组,差异具有统计学意义(P<0.05)。结论度洛西汀联合曲唑酮治疗抑郁症的效果较好,能有效改善患者的抑郁情况及睡眠情况,提高社会支持水平,改善BDNF、GDNF、5-HT、NSE及S-100B蛋白等血清生化指标水平。

Objective To investigate the clinical effect of duloxetine combined with trazodone in the treatment of patients with depression.Methods A total of 120 patients with depression treated in our hospital from January 2020 to May 2021 were selected as the research objects.According to the different treatment schemes,the patients were divided into group A,group B and group C,with 40 cases in each group.All three groups received psychotherapy after admission,the group A was treated with duloxetine,the group B was treated with trazodone,and the group C was treated with duloxetine combined with trazodone.The depression situation,sleep situation,social support level,serum biochemical indexes levels and clinical efficacy among the three groups were compared.Results After 4 and 8 weeks of treatment,there were significant differences in the HAMD and SDS scores among the three groups(P<0.05);after 4 and 8 weeks of treatment,the HAMD and SDS scores of the group A and the group B were higher than those of the group C,and the differences were statistically significant(P<0.05).After treatment,there were significant differences in the ISI,PSQI and SSRS scores among the three groups(P<0.05);after treatment,the ISI and PSQI scores of the group A and the group B were higher than those of the group C,and the SSRS score was lower than that of the group C,the differences were statistically significant(P<0.05).After treatment,there were significant differences in the BDNF,GDNF,5-HT,NSE and S-100B protein levels among the three groups(P<0.05);After treatment,the BDNF,GDNF and 5-HT levels in the group A and the group B were lower than those in the group C,and the NSE and S-100B protein levels were higher than those in the group C,the differences were statistically significant(P<0.05).The total effective rate of treatment in the group A and the group B was lower than that in the group C,and the differences were statistically significant(P<0.05).Conclusion Duloxetine combined with trazodone in the treatment of depression has a significant effect.It can effectively ameliorate the depression situation and sleep situation of patients,improve the social support level,and perfect the serum biochemical indexes levels such as BDNF,GDNF,5-HT,NSE and S-100B protein.