无创吸痰联合雾化吸入治疗小儿毛细支气管炎的临床效果

Clinical effect of noninvasive sputum suction combined with atomization inhalation in the treatment of children with bronchiolitis

目的探讨无创吸痰联合雾化吸入治疗小儿毛细支气管炎的临床效果。方法按照随机数字表法将2019年1月至2021年1月我院儿科收治的180例小儿毛细支气管炎患儿分为对照组和观察组,各90例。对照组实施雾化吸入联合传统吸痰治疗,观察组实施雾化吸入联合无创吸痰治疗。比较两组的临床疗效、症状缓解时间、住院时间、血清炎症因子指标(CRP、PCT、IL-6)、免疫功能指标(CD3^(+)、CD4^(+)/CD8^(+)、IgG、IgA、IgM)、肺通气功能指标(FEV_(1)、FEV_(1)/FVC)及动脉血气指标(PaO_(2)、PaCO_(2)、SpO_(2))。结果观察组的治疗总有效率为96.67%,显著高于对照组的86.67%(P<0.05)。观察组的退热时间、止咳时间、喘憋消失时间、肺啰音消失时间、住院时间均显著短于对照组(P<0.05)。治疗后,两组的血清CRP、PCT、IL-6水平均低于治疗前,且观察组低于对照组(P<0.05)。治疗后,两组的CD3^(+)、CD4^(+)/CD8^(+)、IgG、IgA、IgM水平、FEV_(1)、FEV_(1)/FVC均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组的PaO_(2)、SpO_(2)均高于治疗前,PaCO_(2)均低于治疗前,且观察组优于对照组(P<0.05)。结论无创吸痰联合雾化吸入治疗毛细支气管炎患儿具有良好的效果,可有效缓解患儿的临床症状,减轻机体炎症反应,调节免疫功能,有利于改善肺通气功能及动脉血气状况。

Objective To investigate the clinical effect of noninvasive sputum suction combined with atomization inhalation in the treatment of children with bronchiolitis.Methods According to the random number table method,180 children with bronchiolitis treated in pediatrics department of our hospital from January 2019 to January 2021 were divided into control group and observation group,with 90 cases in each group.The control group was treated with atomization inhalation combined with traditional sputum suction,and the observation group was treated with atomization inhalation combined with noninvasive sputum suction.The clinical efficacy,symptom relief time,hospital stay,serum inflammatory factor indexes(CRP,PCT,IL-6),immune function indexes(CD3^(+),CD4^(+)/CD8^(+),IgG,IgA,IgM),pulmonary ventilation function indexes(FEV_(1),FEV_(1)/FVC)and arterial blood gas indexes(PaO_(2),PaCO_(2),SpO_(2))were compared between the two groups.Results The total effective rate of treatment of the observation group was 96.67%,which was significantly higher than 86.67%of the control group(P<0.05).The antipyretic time,cough relieving time,wheezing and suffocation disappearance time,pulmonary rale disappearance time and hospital stay in the observation group were significantly shorter than those in the control group(P<0.05).After treatment,the leves of serum CRP,PCT and IL-6 in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).After treatment,the CD3^(+),CD4^(+)/CD8^(+),IgG,IgA,IgM levels,FEV_(1) and FEV_(1)/FVC in the two groups were higher than those before treatment,and those in the observation group were higher than the control group(P<0.05).After treatment,PaO_(2) and SpO_(2) in the two groups were higher than those before treatment,PaCO_(2) was lower than that before treatment,and those in the observation group were better than the control group(P<0.05).Conclusion Noninvasive sputum suction combined with atomization inhalation has a good effect in the treatment of children with bronchiolitis,it can effectively alleviate the clinical symptoms of children,reduce the inflammatory reaction of body,regulate immune function,and improve the pulmonary ventilation function and arterial blood gas status.