加味化痰通络汤治疗风痰瘀阻型中风的临床效果及对患者神经功能的影响

Clinical effect of modified Huatan Tongluo decoction on stroke with wind phlegm stasis syndrome and its influence on neurological function

目的探讨加味化痰通络汤治疗风痰瘀阻型中风的临床效果及对患者神经功能的影响。方法将2019年6月至2020年6月我院收治的120例风痰瘀阻型中风患者随机分为对照组和观察组,每组60例。对照组以常规西药治疗,观察组在对照组基础上联合加味化痰通络汤治疗。比较两组的临床疗效、中医证候积分、血清神经细胞因子水平、神经功能及运功功能。结果治疗后,两组的痰证及血瘀证积分均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的S-100β、NSE水平均降低,BDNF水平升高,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗7、14 d后,两组的NIHSS评分降低,MMSE评分升高,且观察组优于对照组,差异具有统计学意义(P<0.05)。治疗15、30 d后,两组的FMA、MAS评分均升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。观察组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。结论加味化痰通络汤治疗风痰瘀阻型中风效果显著,可改善中医证候及血清神经细胞因子水平,促进神经功能及运动功能恢复,值得临床推广。

Objective To explore the clinical effect of modified Huatan Tongluo decoction on stroke with wind phlegm stasis syndrome and its influence on neurological function of patients.Methods A total of 120 stroke patients with wind phlegm stasis syndrome admitted in our hospital from June 2019 to June 2020 were randomly divided into control group and observation group,with 60 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with modified Huatan Tongluo decoction on the basis of the control group.The clinical efficacy,TCM syndromes scores,serum neurocytokines level,neurological function and motor function of the two groups were compared.Results After treatment,the scores of phlegm syndrome and blood stasis syndrome in both groups decreased,those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of S-100βand NSE in both groups decreased,the level of BDNF increased,those in the observation group were better than the control group,and the differences were statistically significant(P<0.05).After 7 and 14 d of treatment,NIHSS score decreased and MMSE score increased in both groups,those in the observation group were better than the control group,and the differences were statistically significant(P<0.05).After 15 and 30 d of treatment,FMA and MAS scores of the two groups increased,those in the observation group were higher than the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Modified Huatan Tongluo decoction in the treatment of stroke with wind phlegm stasis syndrome has a significant effect,it can improve the TCM syndrome and the serum neurocytokines level,and promote the recovery of neurological function and motor function,which is worthy of clinical promotion.