基于数据挖掘技术探析隐白穴主治优势病症和配伍规律

Analysis of clinical indications of acupoint Yinbai(SP1)and its compatible regularities based on data mining technology

目的:运用现代统计学和数据挖掘技术,探析隐白穴主治优势病症和配伍规律。方法:以中华人民共和国成立为时间节点,通过检索隐白穴主治病症及腧穴配伍等相关文献资料,建立SQL Server数据库,运用Gephi可视化软件、SPSS Statistics 25.0及SPSS Modeler统计软件对数据进行频次分析、聚类分析和关联规则分析。结果:中华人民共和国成立前,隐白穴的单穴优势病症12种,分别为气喘满、腹胀满、呕吐、血证、泄泻、崩漏、足胫寒热、不欲食饮、尸厥、腹中寒热、太阴经中风无汗身凉、消渴;配伍主治优势病症20种,分别为失眠多梦、血证、状如尸厥、尸厥、神志类、消渴、癫狂、呕吐、疔证、腹胀满、泄泻、烦闷、中风后遗症、足胫寒热、心胸痞、不欲食饮、水郁不降、气逆、黄疸、痢疾;其配伍腧穴归经前3位分别为足阳明胃经、足太阳膀胱经、足太阴脾经。中华人民共和国成立后,隐白穴的单穴主治优势病症2种,分别为崩漏、月经过多;配伍主治优势病症10种,分别为崩漏、中风后遗症、失眠多梦、痹症、癔症、中风、癫狂、月经过多、郁证、痛经;配伍腧穴归经前3位分别为足太阴脾经、任脉、足阳明胃经。中华人民共和国成立前后配伍腧穴以厉兑、少商、足三里、三阴交、关元关联程度最高,并通过聚类分析得出9个有效聚类群用作隐白穴潜在处方。结论:中华人民共和国成立前,隐白单穴和配伍处方均多用于治疗内科疾病;中华人民共和国成立后隐白单穴多用于治疗妇科疾病,而配伍处方多用于妇科疾病和精神疾病。隐白常用的配伍腧穴有厉兑、少商、足三里、三阴交和关元。

Objective To explore the dominant indications and laws of acupoint compatibility of Yinbai(SP1)by using modern statistics and data mining techniques.Methods Literature about indications and acupoint prescriptions of SP1 published before October of 1949 were retrieved from books Chinese Medical Dictionary(5th edition)and Collection of Modern Medical Journals of Traditional Chinese Medicine,and those published from October 1st of 1949 to January of 2021 retrieved from databa-ses of CNKI,Wanfang,VIP,CBM,Web of Science and Pubmed by using key words of Yinbai(SP1),“Guilei”(鬼垒),“Guiyan”(鬼眼)and Jing(Well)-point of Spleen Meridian,followed by screening the data and establishing a SQL Server database after standardized processing.Then,the descriptive analysis,clustering analysis and association rule analysis were conducted by using Gephi visualization software,SPSS Statistics 25.0 and SPSS Modeler,separately.Results Before October of 1949,the single SP1 acupoint was usually used to treat 12 types of diseases(mainly the internal diseases as asthma,abdominal distension,vomiting,etc.),and the compound prescriptions of SP1 were usually used to treat 20 types of diseases(mainly the internal diseases as insomnia and dreamful sleep,blood syndrome,etc.),and its adjunct acupoints belong to the first three meridians:the Foot Yangming Stomach Meridian,Foot Taiyang Bladder Meridian and Foot Taiyin Spleen Meridian.After October of 1949,the single SP1 was used to dominantly treat 2 types of diseases(mainly the gynecological diseases as metrorrhagia and metrostaxis,and hypermenorrhea,etc.),and the compound prescriptions of SP1 were frequently used to treat 10 diseases(metrorrhagia and metrostaxis,sequela of apoplexy,mental disorders,insomnia and dreamful sleep,etc.),and the adjunct acupoints of compound prescriptions belong to the first three meridians,namely the Foot Taiyin Spleen Meridian,Concept Vessel and Foot Yangming Stomach Meridian.Before and after October of 1949,the adjunct acupoints with the highest degree of correlation were Lidui(ST45),Shaoshang(LU11),Zusanli(ST36),Sanyinjiao(SP9),and Guanyuan(CV4).Cluster analysis showed that 9 effective clusters obtained may be used as potential prescriptions of SP1,and association rule analysis displayed that the first three strongly connected acupoint matching groups were:SP1-ST45,SP1-LU11,and SP1-ST36 frequently used before October of 1949,and SP1-SP9,SP1-ST36 and SP1-CV4 employed after October of 1949.Conclusion Data mining technology reveals that acupoint SP1 alone is mainly used to treat internal diseases before 1949,and gynecological diseases after 1949;and compound acupoint recipes of SP1 are mainly to treat the internal diseases before 1949,and the gynecological diseases and mental disorders after 1949 in China.The frequently employed adjunct acupoints of SP1 are ST45,LU11,ST36,SP9 and CV4 both before and after 1949.