视网膜静脉阻塞的预后与检验指标的相关分析

Analysis of the Prognosis of Retinal Vein Occlusion and its Association with Laboratory Tests

目的探讨雷珠单抗治疗视网膜静脉阻塞继发黄斑水肿的预后与炎症因子及血脂水平的相关性。方法根据治疗前后黄斑中心凹厚度下降程度将视网膜静脉阻塞继发黄斑水肿患者分为疗效良好组(A组,CMT下降≥150μm)和疗效不良组(B组,CMT下降<150μm),检测两组患者治疗前后炎症因子及血脂水平的变化。结果53例患者中A组36例,B组17例。A组治疗前后中性粒细胞数(P<0.001)、C反应蛋白(P=0.003)、总胆固醇(P<0.001)及甘油三酯(P=0.001)改变具有统计学差异,而B组治疗前后炎症因子及血脂水平无统计学差异。结论视网膜静脉阻塞继发黄斑水肿患者接受雷珠单抗治疗后,其炎症因子及血脂水平改变与患者预后具有相关性,可作为疗效判断的辅助指标。

Objective To investigate the prognosis of the patients with macular edema secondary to retinal vein occlusion(RVO)receiving the treatment of ranibizumab and its association with inflammation and blood lipid levels.Methods According to the reduction in central macular thickness before and after treatment,the patients were divided into two groups,good prognosis group(group A,CMT reduction≥150μm)and poor prognosis group(group B,CMT reduction<150μm).The changes in inflammation and blood lipid levels before and after treatment were detected in the two groups.Results Among 53 patients,there were 36 cases in group A and 17 cases in group B.Neutrophils(P<0.001),C-reactive protein(P=0.003),total cholesterol(P<0.001)and triglycerides(P=0.001)were statistically different in group A.There was no statistically difference in inflammation and blood lipid levels in group B before and after treatment.Conclusion After ranibizumab treatment for the patients with macular edema secondary to RVO,the changes in inflammation and blood lipid levels are related to the prognosis,which can be used as auxiliary indicators for the prediction of curative effect.