摘要
糖皮质激素性骨质疏松症(glucocorticoid osteoporosis,GIOP)是继发性骨质疏松症(secondary osteoporosis)最常见的表现形式,对患者健康可造成严重不良影响。GIOP的病理机制较复杂,糖皮质激素对成骨细胞、破骨细胞、骨细胞的影响各不相同,目前GIOP发病机制尚不完全明确。现就近年来GIOP发病机制研究进展作一综述,以明确GIOP治疗方法,从而能开发新型、有效的治疗手段,对减轻个人及社会的经济负担具有重要意义。
Glucocorticoid osteoporosis(GIOP)is the most common manifestation of secondary osteoporosis,which can cause serious adverse effects of the patients'health.The pathological mechanism of GIOP is complex.The effects of glucocorticoids on osteoblasts,osteoclasts and osteoblasts are different.At present,the understanding of GIOP is not completely clear.This paper reviewed the research progress on the pathogenesis of GIOP in recent years to help clarify the treatment methods of GIOP and develop new and effective treatment methods,which is of great significance to reduce the economic burden of individuals and society.
作者
王泽昊
孙东倩
李天佐
夏光涛
唐勇
WANG Zehao;SUN Dongqian;LI Tianzuo;XIA Guangtao;TANG Yong(School of Clinical Medicine,Weifang Medical University,Weifang 261042,Shandong Province,China;Department of Rheumatology and Immunology,Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong Province,China;Department of Health Care,Weifang People's Hospital,Weifang 261000,Shandong Province,China)
出处
《世界临床药物》
2022年第1期5-10,共6页
World Clinical Drug
基金
山东省自然科学基金面上项目:miR-326与Th17/Treg、APE、Ref-1相互作用对自身免疫性肝炎影响研究(ZR2021MH265)。
