血塞通注射液联合丁苯酞治疗急性脑梗死患者的效果

Effects of Xuesaitong injection combined with Butylphthalide in treatment of patients with acute cerebral infarction

目的:观察血塞通注射液联合丁苯酞治疗急性脑梗死患者的效果。方法:选取180例急性脑梗死患者为研究对象,按照随机数字表法分为对照组(n=90)与观察组(n=90),对照组采用丁苯酞氯化钠注射液静脉滴注治疗,观察组在对照组基础上采用血塞通注射液静脉滴注治疗,比较两组临床疗效、美国国立卫生研究院卒中量表(NIHSS)评分、血流动力学指标[阻力指数(RI)、搏动指数(PI)、平均血流速度(Vm)]水平和不良反应发生率。结果:观察组治疗总有效率为95.56%(86/90),明显高于对照组的85.56%(77/90),差异有统计学意义(P<0.05);治疗后,观察组NIHSS评分低于对照组,差异有统计学意义(P<0.05);观察组RI、PI水平均低于对照组,Vm水平高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:血塞通注射液联合丁苯酞治疗急性脑梗死患者,可提高治疗总有效率,改善血流动力学指标水平,降低NIHSS评分,其效果优于单纯丁苯酞治疗。

Objective:To observe effects of Xuesaitong injection combined with Butylphthalide and Sodium chloride injection in treatment of patients with acute cerebral infarction.Methods:180 patients with acute cerebral infarction were selected as the research objects and were divided into control group(n=90)and observation group(n=90)according to the random number table method.The control group was treated by intravenous drip of Butylphthalide and Sodium chloride injection,while the observation group was treated by intravenous drip of Xuesaitong injection on the basis of that of the control group.The clinical efficacy,the National Institutes of Health Stroke Scale(NIHSS)score,the hemodynamic index levels[resistance index(RI),pulsatility index(PI),mean blood velocity(Vm)]and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.56%(86/90),which was significantly higher than the control group of 85.56%(77/90),and the difference was statistically significant(P<0.05).After the treatment,the NIHSS score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The levels of RI and PI in the observation group were lower than those in the control group;the level of Vm was higher than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Xuesaitong injection combined with Butylphthalide and Sodium chloride injection in the treatment of the patients with acute cerebral infarction can improve the total effective rate of treatment,improve the levels of hemodynamic indexes,and reduce the NIHSS score.Moreover,it is superior to single Butylphthalide treatment.