非布司他与别嘌呤治疗4~5期慢性肾病合并高尿酸血症患者的效果比较

Influence of effect and eGFR、BUN、UA level of adding Febuxostatin the Comparison of effects of Febuxostat and Allopurinol in treatment of patients with stage 4-5 chronic kidney disease complicated with hyperuricemia

目的:比较非布司他与别嘌呤治疗4~5期慢性肾病合并高尿酸血症患者的效果。方法:选取138例慢性肾病合并高尿酸血症患者为研究对象,按随机数字表法分成观察组和对照组各69例。对照组采用别嘌醇片口服治疗,观察组采用非布司他口服治疗,比较两组临床疗效、治疗前后肾功能指标[肾小球滤过率(eGFR)、尿素氮(BUN)、血尿酸(UA)]水平,以及不良反应发生率。结果:观察组治疗总有效率为98.55%(68/69),高于对照组的85.51%(59/69),差异有统计学意义(P<0.05);治疗后,观察组eGFR水平高于对照组,BUN和UA水平低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:非布司他治疗4~5期慢性肾脏病合并高尿酸血症患者可提高治疗总有效率,改善肾功能指标水平,其效果优于别嘌醇治疗。

Objective:To compare effects of Febuxostat and Allopurinol in treatment of patients with stage 4-5 chronic kidney disease complicated with hyperuricemia.Methods:138 patients with chronic kidney disease complicated with hyperuricemia were selected as the research objects and were divided into observation group and control group according to the random number table method,69 cases in each.The control group was given oral Allopurinol tablets,while the observation group was given oral Febuxostat.The clinical effects,the renal function index levels[glomerular filtration rate(eGFR),blood urea nitrogen(BUN),serum uric acid(UA)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 98.55%(68/69),which was higher than 85.51%(59/69)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the eGFR level in the observation group was higher than that in the control group;the levels of BUN and UA were lower than those in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Febuxostat in the treatment of the patients with stage 4-5 chronic kidney disease complicated with hyperuricemia can improve the total effective rate of treatment and improve the levels of renal function indexes.Moreover,it is superior to Allopurinol therapy.