头孢哌酮钠舒巴坦钠治疗胆管结石所致胆道感染患者的效果

Effects of Cefoperazone sodium and Sulbactam sodium in treatment of patients with biliary tract infection caused by bile duct stones

目的:观察头孢哌酮钠舒巴坦钠治疗胆管结石所致胆道感染患者的效果。方法:选取63例胆管结石所致胆道感染患者为研究对象,采用随机数字表法分为对照组(n=31)和研究组(n=32)。对照组给予盐酸克林霉素注射液治疗,研究组给予注射用头孢哌酮钠舒巴坦钠治疗,比较两组临床疗效,治疗前后血内毒素、白细胞计数、中性粒细胞计数,血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平,细菌清除率及不良反应发生率。结果:研究组治疗总有效率为96.88%(31/32),高于对照组的74.19%(23/31),差异有统计学意义(P<0.05);治疗后,研究组内毒素、白细胞计数、中性粒细胞计数及血清IL-6、TNF-α、CRP水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);研究组细菌清除率为87.50%(28/32),高于对照组的61.29%(19/31),差异有统计学意义(P<0.05)。结论:头孢哌酮钠舒巴坦钠治疗胆管结石所致胆道感染患者可提高治疗总有效率和细菌清除率,降低血内毒素水平、白细胞计数、中性粒细胞计数和炎性指标水平,效果优于盐酸克林霉素治疗。

Objective:To observe effects of Cefoperazone sodium and Sulbactam sodium in treatment of patients with biliary tract infection caused by bile duct stones.Methods:63 patients with biliary tract infection caused by bile duct stones were selected as the research objects,and were divided into control group(n=31)and study group(n=32)by using the random number table method.The control group was treated with Clindamycin hydrochloride injection,while the study group was treated with Cefoperazone sodium and Sulbactam sodium for injection.The clinical efficacy,the levels of blood endotoxin,white blood cell count,neutrophil count,serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)before and after the treatment,the bacterial clearance and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 96.88%(31/32),which was higher than the control group of 74.19%(23/31),and the difference was statistically significant(P<0.05).After the treatment,the levels of endotoxin,white blood cell count,neutrophil count,serum IL-6,TNF-αand CRP in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The bacterial clearance rate of the study group was 87.50%(28/32),which was higher than the control group of 61.29%(19/31),and the difference was statistically significant(P<0.05).Conclusions:Cefoperazone sodium and Sulbactam sodium in the treatment of the patients with biliary tract infection caused by bile duct stones can improve the total effective rate and the bacterial clearance rate,and reduce the levels of blood endotoxin,white blood cell count,neutrophil count and inflammatory indexes.Moreover,it is superior to Clindamycin hydrochloride treatment.