容积旋转调强放疗与调强适形放疗治疗脑胶质瘤患者的效果比较

Comparison of effects of volume-rotation intensity-modulated radiotherapy and intensity-modulated conformal radiotherapy in treatment of brain glioma patients

目的:比较容积旋转调强放疗(VMAT)与调强适形放疗(IMRT)治疗脑胶质瘤患者的效果。方法:选取86例脑胶质瘤患者为研究对象,按随机数字表法将其分为观察组与对照组各43例。观察组采用VMAT治疗,对照组采用IMRT治疗,比较两组临床疗效、治疗前后表皮生长因子(EGF)水平、血管内皮生长因子(VEGF)水平、卡氏功能状态(KPS)评分、健康状态调查简表(SF-36)评分和不良反应发生率。结果:观察组治疗总有效率为88.37%(38/43),高于对照组的69.77%(30/43),差异有统计学意义(P<0.05);治疗后,观察组EGF和VEGF水平均低于对照组,KPS和SF-36评分均高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为25.58%(11/43),低于对照组的48.84%(21/43),差异有统计学意义(P<0.05)。结论:VMAT治疗脑胶质瘤患者可提高治疗总有效率、KPS评分和SF-36评分,降低EGF水平、VEGF水平和不良反应发生率,效果优于IMRT治疗。

Objective:To compare effects of volume-rotation intensity-modulated radiotherapy(VMAT)and intensity-modulated conformal radiotherapy(IMRT)in treatment of brain glioma patients.Methods:86 patients with brain glioma were selected as the research objects,and were divided into observation group and control group according to the random number table method,43 cases in each group.The observation group was treated with VMAT,while the control group was treated with IMRT.The clinical efficacy,the levels of epidermal growth factor(EGF)and vascular endothelial growth factor(VEGF)levels,the Karnofsky performance scale(KPS)score,the MOS 36-item short-form health survey(SF-36)score and incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 88.37%(38/43),which was higher than the control group of 69.77%(30/43),and the difference was statistically significant(P<0.05).After the treatment,the levels of EGF and VEGF in the observation group were lower than those in the control group;the KPS and SF-36 scores were higher than those in the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 25.58%(11/43),which was lower than 48.84%(21/43)in the control group,and the difference was statistically significant(P<0.05).Conclusions:VMAT in the treatment of the brain glioma patients can improve the total effective rate,the KPS score and the SF-36 score,and reduce the levels of EGF and VEGF and the incidence of adverse reactions.Moreover,it is superior to IMRT treatment.