胃复春片辅助常规西药治疗老年慢性萎缩性胃炎临床研究

Clinical Study on Weifuchun Tablets Assisting Routine Western Medicine for Senile Chronic Atrophic Gastritis

目的:观察胃复春片辅助常规西药治疗老年慢性萎缩性胃炎(CAG)的临床疗效及对炎症因子的影响。方法:回顾性选取164例老年CAG患者临床资料,根据治疗方式分为对照组和观察组各82例。对照组给予酒石酸西尼必利片口服,观察组在对照组基础上加用胃复春片辅助治疗。比较2组治疗前后症状评分、炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞介素-8 (IL-8)]和氧化应激指标[一氧化氮(NO)、超氧化物歧化酶(SOD)],统计分析临床疗效和不良反应发生率。结果:观察组总有效率为97.56%,高于对照组87.80%,差异有统计学意义(P<0.05)。治疗后,2组乏力、隐痛、胃脘胀满和纳差评分较治疗前降低,且观察组乏力、隐痛、胃脘胀满和纳差评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,2组IL-6、TNF-α、IL-8水平较治疗前降低,且观察组IL-6、TNF-α、IL-8水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,2组NO、SOD水平较治疗前升高,且观察组NO、SOD水平高于对照组,差异有统计学意义(P<0.05)。2组不良反应发生率比较,差异无统计学意义(χ^(2)=2.939,P=0.086)。结论:胃复春片辅助常规西药治疗老年CAG效果确切,可改善患者临床症状和氧化应激水平,降低炎症反应,不良反应少。

Objective: To observe the clinical effect of the therapy of Weifuchun tablets assisting routine western medicine on senile chronic atrophic gastritis(CAG) and its effect on inflammatory factors. Methods:A total of 164 cases of clinical data of elderly patients with CAG were retrospectively selected and divided into the control group and the observation group according to the treatment methods, with 82 cases in each group. The control group was treated with oral administration of cinitapride hydrogen tartrate tablets, and the observation group was additionally treated with Weifuchun tablets based on the treatment of the control group. Before and after treatment,the symptom scores,inflammatory factors,including interleukin-6(IL-6), tumor necrosis factor-α(TNF-α) and interleukin-8(IL-8), and oxidative stress indicators,including nitric oxide(NO) and superoxide dismutase(SOD), in the two groups were compared. The clinical effects and incidences of adverse reactions were statistically analyzed. Results:The total effective rate was 97.56% in the observation group, higher than that of 87.80% in the control group, the difference being significant(P<0.05). After treatment, the scores of fatigue,dull pain,stomach cavity fullness and poor appetite in the two groups were decreased when compared with those before treatment,and the above scores in the observation group were lower than those in the control group,the difference being significant(P<0.05). After treatment,the levels of IL-6,TNF-α and IL-8 in the two groups were decreased when compared with those before treatment,and the above levels in the observation group were lower than those in the control group,differences being significant(P<0.05). After treatment,the levels of NO and SOD in the two groups were increased when compared with those before treatment,and the above levels in the observation group were higher than those in the control group, the difference being significant(P<0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(χ^(2)=2.939, P=0.086). Conclusion: The therapy of Weifuchun tablets assisting routine western medicine for senile CAG has a definite effect,which can improve the symptoms and oxidative stress level,and reduce the inflammatory responses,with few adverse reactions.