扶正固本汤联合穴位注射治疗恶性肿瘤化疗相关恶心呕吐的临床研究

Clinical Study on Fuzheng Guben Tang Combined with Acupoint Injection for Chemotherapy-Induced Nausea and Vomiting

目的:观察扶正固本汤联合穴位注射治疗恶性肿瘤化疗相关恶心呕吐(CINV)的临床疗效。方法:选取96例CINV患者,按随机数字表法分为对照组及观察组各48例。对照组采用穴位注射治疗,观察组在对照组基础上给予扶正固本汤治疗。观察2组临床疗效,比较2组治疗前后中医证候积分、T细胞免疫功能(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))、生命质量评价量表(QLQ-C30)、卡氏功能状态(KPS)评分变化,观察2组不良反应发生情况。结果:观察组临床疗效总有效率为97.92%,高于对照组79.17%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分均较治疗前降低,观察组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组T细胞亚群CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)指标值均较治疗前上升,观察组上述4项指标值均高于对照组,差异均有统计学意义(P<0.05)。治疗后,2组QLQ-C30评分、KPS评分均较治疗前升高,观察组上述2项评分均高于对照组,差异均有统计学意义(P<0.05)。2组均给予血压、肝功、血尿常规等监测,其中对照组2例、观察组1例出现注射处红肿,经诊治为药物吸收不良所致,给予对症热敷治疗,未影响本次研究,其余未发现异常。结论:扶正固本汤联合穴位注射治疗CINV可提高临床疗效,缓解临床症状,提高机体免疫力,提升生活质量,且该治疗方案安全性较高。

Objective:To observe the clinical effect of Fuzheng Guben tang combined with acupoint injection for chemotherapy-induced nausea and vomiting(CINV).Methods:A total of 96 cases of CINV patients were divided into the control group and the observation group according to the random number table method,with 48 cases in each group.The control group was treated with acupoint injection,and the observation group was additionally treated with Fuzheng Guben tang based on the treatment of the control group.The clinical effects in the two groups were observed.Before and after treatment,the changes in Chinese medicine syndrome scores,immune function of T-lymphocytes(CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)),scores of Quality of Life Questionnaire(QLQ-C30) and Karnofsky Performance Score(KPS) in the two groups were compared.The incidences of adverse reactions in the two groups were observed.Results:The total effective rate of clinical effect was 97.92%in the observation group,higher than that of 79.17%in the control group,the difference being significant(P<0.05).After treatment,the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in the observation group was lower than that in the control group,differences being significant(P<0.05).After treatment,the values of T lymphocyte subsets including CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)in the two groups were increased when compared with those before treatment,and the above four values in the observation group were higher than those in the control group,differences being significant(P<0.05).After treatment,the scores of QLQ-C30 and KPS in the two groups were increased when compared with those before treatment,and the above two scores in the observation group were higher than those in the control group,differences being significant(P<0.05).After monitoring on blood pressure,liver function and blood and urinary routine in the two groups,there was redness and swelling in the injection place in two cases in the control group and one case in the observation group,which was induced by poor drug absorption after diagnosis and treatment.After symptomatic hot compress,it did not affect the study,and no other abnormalities were found.Conclusion:Fuzheng Guben tang combined with acupoint injection for CINV can improve clinical effect,immunity,quality of life and relieve clinical symptoms,with higher treatment safety.