偏头痛的药物及非药物治疗研究进展

Advances in Pharmacological and Non-pharmacological Treatment of Migraine

目的偏头痛是一种常见的原发性头痛,作用机制不是完全明了,治疗上也存在诸多局限。以降钙素基因相关肽为靶点研发出偏头痛预防治疗药物是近几十年来偏头痛治疗领域最重要的突破。此外,较少引起血管收缩不良反应的5-羟色(5-HT);受体激动剂也在急性偏头痛治疗中显示出良好的应用前景。与此同时,非侵入性神经调控治疗也连续被批准用于偏头痛的预防以及发作期的治疗。

Migraine is a common primary headache disorder. The mechanisms for migraine are not completely understood, and limitation in treatment persists. Monoclonal antibodies against the calcitonin gene-related peptide(CGRP) receptor revolutionized migraine treatment, and it has been regarded as the most important breakthrough in migraine preventive treatment in recent decades. In addition, 5-HT;receptor agonists, which is devoid of vasoconstrictive effects, shows a good application prospect in acute migraine treatment. Meanwhile, non-invasive neurostimulation methods have been proposed for acute or preventive migraine treatment.