磁共振动态增强参数及miR-27、miR-155表达与乳腺癌的关联性

Correlation of DCE-MRI Parameters and Expression of miR-27 and miR-155 with Breast Cancer

探究磁共振动态增强、miR-27、miR-155表达与乳腺癌的关联性。选取100例乳腺癌患者作为观察组,另选取60例乳腺良性病变患者作为对照组。比较两组DCE-MRI定量参数[转运常数(K_(trans))、速率常数(K_(ep))、血管外细胞间隙体积分数(c)]与miR-27、miR-155表达,进行相关性分析,并评价其诊断效能。结果显示,观察组K_(trans)、K_(ep)、miR-27和miR-155表达水平较对照组高(P<0.05);K_(trans)、K_(ep)与miR-27和miR-155表达水平呈显著正相关(P<0.05);K_(trans)、K_(ep)、miR-27、miR-155为乳腺癌发生的独立影响因素(P<0.05);K_(trans)、K_(ep)、miR-27和miR-155表达与组织学分级、临床分期、淋巴结转移、孕激素及雌激素受体表达有关(P<0.05);DCE-MRI定量参数、miR-27和miR-155表达联合诊断乳腺癌的AUC为0.905。乳腺癌发生DCE-MRI定量参数(K_(trans)、K_(ep))与miR-27、miR-155表达水平均上调,且与病理特征有关。

The purpose of this study was to explore the relationship between dynamic enhancement of magnetic resonance,miR-27,miR-155 expression and breast cancer.One hundred breast cancer patients were selected as the observation group,and another 60 patients with benign breast lesions were selected as the control group.This study compared the two groups’DCE-MRI quantitative parameters[transport constant(K_(trans)),rate constant(K_(ep)),extravascular intercellular space fraction(V_(e))]and the expression of miR-27 and miR-155,and then performed correlation analysis to evaluate its diagnostic power.The expression levels of K_(trans),K_(ep),miR-27 and miR-155 in the observation group were higher than those in the control group(P<0.05).The expression levels of K_(trans) and K_(ep) in breast cancer patients were significantly positively correlated with the expression levels of miR-27 and miR-155(P<0.05).K_(trans),K_(ep),miR-27 and miR-155 were independent influencing factors of breast cancer(P<0.05).The expression of K_(trans),K_(ep),miR-27,miR-155 is related to histological grade,clinical stage,lymph node metastasis,progesterone and estrogen receptor expression(P<0.05).The AUC of the combined diagnosis of breast cancer by DCE-MRI quantitative parameters,miR-27,miR-155 expression is 0.905.DCE-MRI quantitative parameters(K_(trans),K_(ep))and the expression levels of miR-27 and miR-155 were up-regulated in breast cancer,and were related to pathological features.