超声造影时间-强度曲线参数评估膀胱癌分期的研究

Study on the Time-intensity Curve Parameters of Contrast-enhanced Ultrasound in Evaluating the Preoperative Staging of Bladder Cancer

本次研究的目的是探讨超声造影在膀胱癌患者术前分期中的应用价值。选取膀胱癌患者90例,给予超声造影检查,比较超声造影与术后病理结果。超声造影术前T分期与术后病理Kappa值为0.699(P<0.05),诊断准确率为76.67%;超声造影术前N分期与术后病理Kappa值为0.705(P<0.05),诊断准确率为84.40%;低级别膀胱癌半洗漱时间(TPH)明显低于高级别膀胱癌(P<0.05),而半降支斜率(DS)明显高于高级别膀胱癌(P<0.05);TPH、DS鉴别低级别膀胱癌的ROC曲线下面积分别为0.766和0.709(P<0.05);TPH、DS鉴别低级别膀胱癌的灵敏性分别为72.90%和62.50%,特异性分别为71.40%和76.20%。超声造影在膀胱癌术前评估中有较好的应用价值。

The purpose of this study was to discussed the value of contrast-enhanced ultrasound(CEUS) in preoperative staging of ladder cancer. A total of 90 patients with bladder cancer treated were selected for contrast-enhanced ultrasonography and compared with the postoperative pathological results. The Kappa value of preoperative T-stage of contrast-enhanced ultrasound and postoperative pathological results was 0.699(P<0.05), and the diagnostic accuracy was 76.67%. The Kappa value of preoperative N-stage of contrast-enhanced ultrasound and postoperative pathological results was 0.705(P<0.05), and the diagnostic accuracy was 84.40%. The time from peak to one half(TPH) of low-grade bladder cancer was significantly lower than that of higher-grade bladder cancer(P<0.05), and the semi-descending slope(DS) was significantly higher than that of higher-grade bladder cancer(P<0.05). The area under ROC curve of TPH and DS for the differentiation of low-grade bladder cancer were 0.766 and 0.709(P<0.05). The sensitivity of TPH and DS were 72.90% and 62.50%, and the specificity were 71.40% and 76.20%, respectively. Contrast-enhanced ultrasound has a good application value in preoperative evaluation of bladder cancer.