肺-肠轴:儿童呼吸道感染与肠道微生态的相关性

Lung-gut axis:the microbial crosstalks in children with respiratory tract infection

肠道菌群是作为维持器官微环境的重要调节剂,由肠道-重要器官轴发挥作用。多项研究表明,肠道菌群及其代谢产物可有效预防和治疗呼吸系统疾病。然而,由于儿童肠道菌群的组成与成年人不同,并且其免疫系统正处于发育过程中,因此关于儿童肠道菌群与呼吸道感染之间相互作用的研究仍然很少。该文从“肺-肠轴”角度介绍了呼吸道感染儿童肠道菌群的变化,并分析了儿童肠道菌群与免疫功能和呼吸道感染之间的相关性,期望能为临床从肠道菌群入手治疗儿童呼吸道感染提供参考。

Gut microbiota,as an important regulator of maintaining organ microenvironment,composes of the gut-organ axis.Many evidences have shown that gut microbiota and its metabolites can be used as a therapeutic strategy to effectively prevent and treat respiratory diseases.However,because the composition of children’s gut microbiota is different from that of adults and the dynamic development of immune system,researches on the interaction between children’s gut microbiota and respiratory infection remains scarce.Here,we introduced the changes in the gut microbiota of children with respiratory tract infection from the perspective of lunggut axis,and analyzed the relationship between the gut microbiota and immune function of children and respiratory infection,aiming to provide reference for clinical treatment of pediatric respiratory infection from the aspect of gut microbiota.