氯雷他定联合糠酸莫米松鼻喷剂及玉屏风颗粒对重度变应性鼻炎患者的临床疗效及对体征评分、炎性因子、不良反应的影响分析

Clinical efficacy of loratadine combined with mometasone furoate nasal spray and Yupingfeng granule on the treatment of severe allergic rhinitis and analysis of its influence on physical sign score,inflammatory factor,adverse reactions

目的探讨氯雷他定联合糠酸莫米松鼻喷剂及玉屏风颗粒对重度变应性鼻炎患者的临床疗效。方法选择2020年4月—2021年4月本院60例肺脾气虚型重度AR患者作为研究对象,按随机数表法分为研究组和对照组两组,每组各30例。对照组患者仅接受常规西药(氯雷他定、糠酸莫米松)治疗,研究组患者在对照组西药基础上联用玉屏风颗粒,两组患者均治疗2个月。比较两组患者治疗前后中医症候积分、中西医疗效、治疗前后C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子(TNF)水平及不良反应。结果治疗前,两组患者的鼻塞、鼻涕、喷嚏、鼻痒、总积分比较,差异无统计学意义(P>0.05);治疗后,研究组患者的鼻塞、鼻涕、喷嚏、鼻痒、总积分低于对照组,差异具有统计学意义(P<0.05);研究组患者治疗总有效率(96.67%)明显高于对照组(80.00%),差异有统计学意义(P<0.05);治疗前,两组患者的CRP、IL-6、TNF水平比较,差异无统计学意义(P>0.05);治疗后,研究组患者的CRP、IL-6、TNF水平低于对照组,差异具有统计学意义(P<0.05);两组患者不良反应发生率(13.33%,10.00%)比较,差异无统计学意义(P>0.05)。结论玉屏风颗粒联合氯雷他定、糠酸莫米松可有效降低重度AR患者中医症候积分及血清炎性因子表达水平,提高患者临床治疗效果及预后质量。

Objective To observe the clinical effect of loratadine combined with mometasone furoate nasal spray and Yupingfeng granule on patients with severe allergic rhinitis(AR).Methods From April 2020 to April 2021,60 patients with severe AR of lung spleen qi deficiency type were enrolled as study objects,and they were randomly divided into control group and study group according to random number table method,with 30 cases in each group.Patients in the control group were treated with loratadine and mometasone furoate,while the patients in the study group were treated with Yupingfeng granules on the basis of western medicine,the treatment in both two groups were lasted for 2 months.TheTCM syndrome score and C-reactive protein(CRP)and interleukin-6(IL-6)and tumor necrosis factor(TNF)levels of the two groups before and after treatment,the efficacy of traditional Chinese medicineand western medicine,and adverse reactions were compared.Results Before treatment,there was no significant difference in nasal obstruction,nasal mucus,sneezing,nasal itching,and total score between the two groups(P>0.05).After the treatment,the scores of nasal obstruction,nasal mucus,sneezing,nasal itching,and total score of the study group were lower than those of the control group(P<0.05).The total effective rate of the study group was 96.67%,which was higher than 80.00%of the control group(P<0.05).Before the treatment,there were no significant differences in levels of CRP,IL-6 and TNF between the two groups(P>0.05).After treatment,CRP,IL-6,TNFin the study group were significantly lower than those in the control group(P<0.05).There was no significant difference in the total adverse reaction rate between the two groups(13.33%vs 10.00%)(P>0.05).Conclusions Yupingfeng granule combined with loratadine and mometasone furoate could effectively reduce the TCM syndrome score and serum inflammatory factor expression level of patients with severe AR,and improve the clinical treatment effect and prognosis quality of patients.