TAM对TgAb阳性分化型甲状腺癌远处转移的预测价值

Predictive value of TAM for distant metastasis in differentiated thyroid cancer with positive TgAb

目的探讨血清肿瘤相关物质(TAM)对甲状腺球蛋白抗体(TgAb)阳性的分化型甲状腺癌远处转移的预测价值。方法收集377例TgAb阳性的分化型甲状腺癌(DTC)患者资料,采用免疫比色法测定其血清TAM水平。根据有无远处转移将患者分为无远处转移组(321例)和远处转移组(56例)。通过受试者工作特性(ROC)曲线评估了TAM预测TgAb阳性的DTC患者远处转移的价值。结果远处转移组TAM水平高于无远处转移组(P<0.05)。TAM具有良好的诊断价值,最佳截断值为94.27 U/mL,诊断TgAb阳性DTC患者远处转移的灵敏度为71.43%,特异度为81.93%,诊断准确率为80.37%,ROC曲线下面积为0.832(P<0.05)。结论TAM对TgAb阳性DTC患者的远处转移具有良好的预测价值。

Objective To investigate the predictive value of serum tumor-associated material(TAM)for distant metastasis in differentiated thyroid cancer(DTC)patients with positive thyroglobulin antibody(TgAb).Methods A total of 377 DTC patients with positive TgAb were selected,and serum TAM of the patients was measured by immunosorbent colorimetry assay.According to the presence or absence of distant metastasis,patients were divided into the no distant metastasis group(M0 group)and the distant metastasis group(M1 group),321 patients in the M0 group and 56 patients in the M1 group.The value of TAM in predicting distant metastasis in TgAb positive DTC patients was assessed by the receiver operating characteristic(ROC)curve.Results The level of TAM in the M1 group was higher than that in the M0 group(P<0.05).TAM presented a good diagnostic value,with a sensitivity of 71.43%,a specificity of 81.93%,a diagnostic accuracy of 80.37%and an area under the ROC curve of 0.832(P<0.05)for diagnosing distant metastasis at the optimal cut-off value of 94.27 U/mL.Conclusion TAM has a good predictive value for distant metastasis in DTC patients with positive TgAb.