Edmonton虚弱量表预测急性冠状动脉综合征结局的meta分析

Meta-analysis of the role of Edmonton scale on major adverse cardiovascular events in patients with acute coronary syndrome

目的探究Edmonton虚弱量表评分预测急性冠状动脉综合征(ACS)患者全因死亡率的影响。方法计算机检索PubMed、Embase、中国知网和中国生物医学文献数据库(CBM),检索时限为自建库至2021年2月28日,收集虚弱评分预测ACS患者结局的临床研究,主要终点事件定义为全因死亡率。2名研究人员独立筛选文献,用NOS对文献质量进行评价,提取关键信息,使用Stata13.1软件进行meta分析。结果共纳入4项研究,共736例患者。其中虚弱组302例,其中103例发生死亡;非虚弱组434例,其中50例发生死亡。meta分析显示与不虚弱患者相比,虚弱患者发生全因死亡率的风险明显升高[RR=2.817(2.066,3.840),P<0.05]。结论入院时ACS患者虚弱程度能预测其全因死亡率。

Objective To explore the effect of the Edmonton Frailty Scale score on predicting all-cause mortality in the patients with acute coronary syndrome(ACS).Methods PubMed,Embase,China National Knowledge Infrastructure(CNKI)and China Biomedical Literature Database(CBM)were screened from the establishment of the database to February 28,2021.The clinical studies on the application of the Edmonton scale to predict the outcome of the patients with ACS were collected.The primary endpoint event was defined as all-cause mortality.The literature were screened independently by two researchers,using the Newcastle-Ottawa Scale to evaluate the quality of the literature and extract the significant information.Stata13.1 was used to conduct the meta-analysis.Results A total of four studies were included,including 736 patients.Among them,there were 302 ACS patients in the frailty group,of which 103 died.A total of 434 ACS patients were in the non-frailty group,of which 50 died.The meta-analysis showed that compared with that of the non-frail patients,the risk of all-cause mortality in the frail patients was significantly higher[RR=2.817(2.066,3.840),P<0.05].Conclusion The frailty of the ACS patients on admission could predict their all-cause mortality.