基于微量合成的药物发现研究进展

Research Advances in Drug Discovery Based on Miniaturized Synthesis

现代创新药物研发中,化合物库的质量直接影响着整个研发的成功与否。因此,如何快速构建数目庞大、结构多样的高质量化合物库是药物发现中的关键环节。随着微量合成技术与生物活性筛选技术的快速发展,短时间内构建多个高质量化合物库的目标逐渐被实现,新的苗头化合物与先导化合物也随之不断被发现。综述近几年基于微量合成的药物研究最新进展,以期为基于微量合成的新药研发提供参考。

In modern discovery of innovative drugs, the quality of compound library directly affects the success of the whole process of research and development. Thus, how to quickly construct a high-quality library of compounds large in number and rich in structural diversity is a key step in drug discovery. With the rapid development of miniaturized(microscale/nanoscale) synthetic technology and biological screening technology, the goal of constructing multiple high quality compound libraries in a short time has been gradually realized, new hit and lead compounds being constantly discovered. Based on the relevant research in recent years, the latest progress in drug discovery through nanoscale synthesis is summarized, aiming to provide new insights to drug discovery based on miniaturized synthesis.