GC7在炎症及缺氧缺血性相关疾病中的作用

The role of GC7 in inflammation and hypoxic-ischemic related diseases

临床上,炎症和缺氧缺血与大多数疾病的病情严重程度及预后等密切相关。真核翻译起始因子5A(eukaryotic translation initiation factor 5A, EIF5A)在线粒体代谢功能的调节及促炎因子的释放中发挥重要作用,影响炎症及缺氧缺血的发生发展。N1-甲眯基-1,7-二氨基庚烷GC7(N1-guany1-1,7-diaminohep-tane)是EIF5A活化中的关键酶[脱氧羧腐胺赖氨酸合酶DHS(deoxyhypusinesynthase)]的抑制剂,可以通过抑制EIF5A的活性,进一步稳定线粒体功能,预防有毒活性氧(reactive oxygen species,ROS)的生成,减少炎症因子的释放,从而改善脑卒中、肾移植、肾缺血等缺氧缺血相关疾病和炎症相关疾病的症状。所以,GC7有望成为临床上治疗炎症和缺氧缺血相关疾病的不错选择。本文对GC7在炎症和缺氧缺血相关疾病中的作用及机制进行综述。

Clinically, inflammation, hypoxia and ischemia are closely related to the severity and prognosis of most diseases. Eukaryotic translation initiation factor 5 A(EIF5 A) plays an important role in the regulation of mitochondrial metabolic function and the release of pro-inflammatory factors affecting the occurrence and development of inflammation and hypoxia-ischemia. It has been found that N1-guany1-1,7-diaminoheptane(GC7) is an inhibitor of deoxycarboxyputrescine lysine synthase DHS, a key enzyme in the activation of EIF5 A. It can further stabilize mitochondrial function, prevent the formation of toxic reactive oxygen species(ROS) and reduce the release of inflammatory factors by inhibiting the activity of EIF5 A to improve the symptoms of hypoxia-ischemia-related diseases and inflammation-related diseases such as stroke,renal transplantation, renal ischemia and so on. Therefore, GC7 is expected to become a good choice for clinical treatment of inflammation and hypoxia-ischemia related diseases. This review discusses the role and mechanism of GC7 in inflammatory and hypoxic-ischemic related diseases.