摘要
巨噬细胞是炎症细胞的重要组成部分,包括促炎M1型和抗炎M2型。两者之间的表型转化决定炎症反应的最终结局。TLR4/NF-κB、MAPK、JAK/STAT、PI3K/AKT和PPAR-γ等是巨噬细胞极化的关键信号通路。在肠、肝、肺、脑等脏器炎性损伤过程中,主要是以M1型巨噬细胞过度活化为主,持续合成、释放炎性因子参与机体的炎性损伤。本文总结了近年来的相关研究,就巨噬细胞极化及其与器官炎性损伤的关系进行阐述,同时探讨中药在调控巨噬细胞极化中的作用,以期为炎症反应性疾病提供新的治疗靶点。
Macrophages are an important part of inflammatory cells, including pro-inflammatory M1 type and anti-inflammatory M2 type. The phenotypic transformation between the two determines the outcome of the inflammatory response, and TLR4/NF-κB, MAPK, JAK/STAT, PI3K/AKT and PPAR-γ, and so on are the key signaling pathways of macrophage polarization. In the process of inflammatory injury of the intestine,liver, lung, brain, and other organs, M1-type macrophages are mainly over-activated, which continuously synthesize and release inflammatory factors to participate in the inflammatory injury of the body. This paper summarizes the relevant research in recent years, expounds the macrophage polarization and its relationship with organ inflammatory injury, and discusses the role of traditional Chinese medicine in regulating macrophage polarization, in order to provide a new therapeutic target for inflammatory diseases.
作者
陈浪
郇轩
余武汉
李腾飞
肖国辉
张有成
CHEN Lang;HUAN Xuan;YU Wuhan;LI Tengfei;XIAO Guohui;ZHANG Youcheng(Department of General Surgery,Second Hospital of Lanzhou University,Lanzhou 730000,China)
出处
《生命的化学》
CAS
2021年第12期2704-2711,共8页
Chemistry of Life
基金
兰州大学第二医院“萃英科技创新”计划项目(CY2018-MS14)
兰州市科技发展指导计划项目(2019-ZD-71)
兰州市城关区科技项目(2014-4-4)
万特尔合作研究研究项目(2020SW-YX032)。
关键词
巨噬细胞极化
炎症反应
信号通路
器官损伤
中药
macrophage polarization
inflammatory response
signaling pathways
organ injury
traditional Chinese medicine