不同浓度亚甲蓝注射用于肛肠病术后镇痛的疗效观察

Anelgesia Efficacy of Methylence Blue Injection at Different Concentrations Following Surgery for Coloproctological Diseases

为分析探讨不同浓度亚甲蓝注射用于肛肠病术后镇痛的临床效果,将200例肛肠手术患者随机分为A、B、C、D 4组,每组50例。A组使用0.24%亚甲蓝混合液肛周创面局部注射,B组使用0.18%亚甲蓝混合液肛周创面局部注射,C组使用0.13%亚甲蓝混合液肛周创面局部注射,D组不使用亚甲蓝,对比观察4组术后不同时点的镇痛效果、肛门感觉恢复时间、愈合时间及不良反应情况。结果显示,手术当天4组患者疼痛程度比较,差异无统计学意义(P>0.05);A组、B组术后1d、3d和7d的疼痛评分均低于C组和D组(P <0.05)。A组肛门感觉恢复时间长于B组和C组(P <0.05),但明显短于D组(P <0.05)。A组、B组和C组创口愈合时间及术后不良反应发生率均优于D组(P <0.05),但3组间比较差异均无统计学意义(P>0.05)。结果表明,肛肠病手术患者使用亚甲蓝术后镇痛,可有效降低患者疼痛程度,加速创面恢复,且安全性较高,以0.18%浓度亚甲蓝混合液局部注射最为适合,临床效果明显。

This study was to investigate the clinical anelgesia efficacy of methylence blue at different concentrations following surgery for coloproctological diseases,randomly divided 200 patients undergoing surgery for coloproctological diseases into group A,B,C and D;50 cases,for each group.In group A,B and C respectively and locally injecting methylence blue mixture injection at 0.24%,0.18%,and 0.13%into patients’ perianal wound-surface was taken,meanwhile in group D did not so;then,observed and compared the four groups’ analgesia efficacy at different time-point,the time for ano-esthesia recovered,the time for wound healing,and unward reaction status.As results,the day of surgery in pain intensity there was no statistical difference between the four groups(P >0.05);at 1 day and 3,7 days after surgery the score ratings on pain of group A and B were lower than that of group C and D(P <0.05);in the time for ano-esthesia recovered group A was longer than group B and C(P <0.05),but significantly shorter than group D(P <0.05),in the incidence of unward reactions,and in wound healing time group A,B,and C were all superior to group D(P <0.05),but between group A,group B,and group C there was no statistical difference(P >0.05).Results show that for the patients undergoing coloproctological diseases’ surgery using methylence blue for postoperative anelgesia can effectively reduce their pain intensity,accelerate woundsurface recovered,and its safety is higher,especially,at the concentration of 0.18%injecting the mixture is optimum,with significant efficacy.