主观认知下降的MRI研究进展

MRI research progress of subjective cognitive decline

主观认知下降(subjective cognitive decline,SCD)是阿尔茨海默病的最早症状,发病率较高。由于缺乏客观量化的诊断金标准,SCD的诊断主要通过临床评估,容易导致误诊和延误治疗。本文就结构磁共振、功能磁共振、弥散张量成像和动脉自旋标记在SCD患者的脑结构和功能方面的应用进展进行综述。目前多模态MRI证实了SCD存在“SCD-轻度认知障碍-阿尔茨海默病”动态进展的趋势,为SCD的早期诊断、认知下降严重程度的评估和预后方面提供更多的评估信息。

Subjective cognitive decline(SCD) is the earliest symptom of Alzheimer’s disease with a high incidence. Due to the lack of objectively quantified diagnostic gold standard, the diagnosis of SCD is mainly through clinical evaluation, which is prone to misdiagnosis and delayed treatment. This article reviewed the application of structural magnetic resonance, functional magnetic resonance, diffusion tensor imaging, and arterial spin labeling in the brain structure and function of patients with SCD. The dynamic progression trend of SCD was confirmed by multimodal MRI, providing more information for the diagnosis of SCD, the assessment of the severity of cognitive decline and the prognosis of SCD.