蒽环类药物所致心脏毒性的磁共振研究进展

Research progress of cardiac magnetic resonance imaging in anthracycline-induced cardiotoxicity

蒽环类药物(anthracycline, ATC)是常见的化疗药物,具有突出的心脏毒性。蒽环类药物所致心脏毒性(anthracycline-induced cardiotoxicity,AIC)是影响癌症患者生存质量的重要因素。准确检测及正确评估AIC能够为临床诊疗提供重要信息,降低癌症患者出现心血管并发症的风险。心脏磁共振(cardiac magnetic resonance,CMR)具有无创、可重复性好、空间分辨率高、多序列成像等优势,在AIC的基线评估及跟踪随访中起到了重要作用。近年来,包括特征追踪(feature-tracking,FT)技术及mapping技术在内的一系列CMR新技术的发展更是在AIC的早期检测方面发挥了重要的作用。本文将对CMR在检测和评估AIC中的应用及研究进展作一综述。

Anthracycline(ATC) is a commonly used chemotherapeutic drug with prominent cardiotoxic side effects.Anthracycline-induced cardiotoxicity(AIC) increases the cardiovascular morbidity and mortality of cancer survivors and seriously affects the quality of their life. Detecting and evaluating the AIC precisely can provide key information for clinical diagnosis and treatment, and reduce cardiovascular complications in cancer survivors. Cardiac magnetic resonance(CMR), as a noninvasive procedure,plays an important role in the baseline evaluation and follow-up of AIC due to its advantages of good repeatability, high spatial resolution, and multiple-parameter-imaging. Recently, series of new CMR technologies, including feature tracking(FT) and mapping,played an irreplaceable role in the early detection of AIC. Here we summarized the technical advantages and the progress of clinical application on CMR detecting and evaluating AIC.