肥胖儿童维生素D水平与胰岛素抵抗相关性研究进展

Study progress of relationship between vitamin D level and insulin resistance in obese children

近年来,肥胖儿童体内维生素D水平与胰岛素抵抗的关系成为研究热点。肥胖儿童体内常伴维生素D减少,维生素D缺乏可通过影响脂肪细胞代谢、炎症反应、氧化应激及线粒体功能等途径增加胰岛素抵抗风险,成为导致儿童肥胖发生、发展的重要原因之一。补充维生素D可改善胰岛素的敏感性,从而改善肥胖患儿的预后。本文就肥胖儿童体内维生素D水平与胰岛素抵抗的关系及其可能机制进行综述。

In recent years,the relationship between vitamin D level and insulin resistance in obese children has become a research hotspot.In obese children,vitamin D level are often reduced,vitamin D deficiency may increase the risk of insulin resistance by affecting adipocyte metabolism,inflammatory responses,oxidative stress and mitochondrial function,it has become one of the important reasons that lead to the occurrence and development of childhood obesity.Vitamin D supplementation can improve insulin sensitivity and thus improve the prognosis of obese children.This article reviews the relationship between vitamin D level and insulin resistance in obese children and its possible mechanism.