NGAL在类风湿关节炎病人动脉粥样硬化中的作用

ROLE OF NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN IN ATHEROSCLEROSIS IN PATIENTS WITH RHEUMATOID ARTHRITIS

目的分析中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在类风湿关节炎(RA)病人动脉粥样硬化(AS)中的作用。方法选择我院收治的RA病人209例,依照是否合并AS分为RA组(C组)和RA合并AS组(D组);选择100例健康者作为A组,50例AS病人作为B组。检测受试者血中基质金属蛋白酶-9(MMP-9)、NGAL、环瓜氨酸肽(CCP)抗体、红细胞沉降率(ESR)、类风湿因子(RF)等指标。采用Logistics回归模型分析NGAL等指标与RA合并AS的关系。结果4组MMP-9、NGAL、CCP抗体、ESR和RF水平比较存在明显差异,其中D组MMP-9、NGAL、CCP抗体、ESR及RF水平最高,差异有统计学意义(F=354.542~2057.146,P<0.05)。病人血中MMP-9、NGAL水平异常升高是影响RA病人AS病情的独立性危险因素,差异有统计学意义(OR=1.857、1.865,95%CI=(1.228~2.831)、(1.310~2.632),P<0.05)。结论NGAL在RA合并AS病人体内高表达,其水平异常升高是影响病情的独立性危险因素。

Objective To investigate the role of neutrophil gelatinase-associated lipocalin(NGAL)in atherosclerosis(AS)in patients with rheumatoid arthritis(RA).Methods A total of 209 patients with RA who were admitted to our hospital were enrolled and divided into RA group(group C)and RA+AS group(group D)according to the presence or absence of AS;100 healthy subjects were enrolled as group A,and 50 patients with AS were enrolled as group B.Related indices were measured,including matrix metalloproteinase-9(MMP-9),NGAL,cyclic citrullinated peptide(CCP)antibody,erythrocyte sedimentation rate(ESR),and rheumatoid factor(RF),and the logistic regression model was used to analyze the association between NGAL and RA with AS.Results There were significant differences in the levels of MMP-9,NGAL,CCP antibody,ESR,and RF between the four groups,and group D had the highest levels of MMP-9,NGAL,CCP antibody,ESR,and RF(F=354.542-2057.146,P<0.05).Abnormally elevated MMP-9 and NGAL in blood were independent risk factors for the condition of AS in patients with RA(MMP-9:OR=1.857,95%CI=1.228-2.831,P<0.05;NGAL:OR=1.865,95%CI=1.310-2.632,P<0.05).ConclusionNGAL is highly expressed in patients with RA and AS,and abnormally elevated NGAL is an independent risk factor for disease condition.