不同新型冠状病毒变异株感染的COVID-19潜伏期研究

The Incubation Period of COVID-19 Caused by Different SARS-CoV-2 Variants

从新型冠状病毒肺炎(COVID-19)疫情初始至今,COVID-19的病原体新型冠状病毒(SARS-CoV-2)不断进化和变异,产生传播力和毒力变化的变异株,如Alpha(B.1.1.7)、Beta(B.1.351)、Gamma(P.1)、Delta(B.1.617.2)以及Omicron(B.1.1.529)变异株。深入研究不同变异株感染所致的COVID-19潜伏期有助于追溯传染源,确定密切接触者的留验、检疫和医学观察期限,为及时调整COVID-19疫情防控措施提供依据。本文主要综述了国内外感染SARS-CoV-2野生株和不同变异株的COVID-19潜伏期的相关研究,研究发现,感染SARS-CoV-2野生株的潜伏期在4~8 d,中位潜伏期约为5.5 d。感染Beta、Gamma变异株的潜伏期与野生株基本类似,约为5 d。感染Alpha、Delta和Omicron变异株的潜伏期则低于其他毒株,分别为4 d、4 d和3 d。

Since the beginning of the COVID-19 epidemic,the pathogen of COVID-19,SARS-CoV-2,has evolved and mutated continuously,producing variants with different enhanced transmission and virulence,such as Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),Delta(B.1.617.2)and Omicron(B.1.1.529).An intensive study of the incubation period of COVID-19 caused by different SARS-CoV-2 variants will contribute to tracing the origin of COVID-19,determining the detention,quarantine and isolation time of close contacts,and timely improving measures for containing COVID-19.We reviewed the major studies on the incubation period of COVID-19 caused by wild-type strains and different variants of SARSCoV-2,which estimated that the incubation period of COVID-19 caused by wild-type SARS-CoV-2 strains was 4-8(median 5.5)days.And that for COVID-19 caused by Beta or Gamma variant was generally similar to that by wild-type strains,about 5 days.The incubation period of COVID-19 caused by Alpha,Delta and Omicron variants was shorter than that of other strains,which was 4,4 and 3 days,respectively.