衰弱老年人中肠道菌群相关研究进展

Progress in gut microbiota related researches in frail elderly

衰弱是常见的老年综合征,是健康老龄化中面临的严峻课题,但其发病机制并不十分明确。目前一致认为衰弱是由多因素导致,其中免疫功能失调和慢性炎症在衰弱中发挥重要作用。由于肠道菌群与免疫功能及慢性炎症相关,因此近年来肠道菌群与衰弱的相关性也逐渐受到关注。本文主要介绍肠道菌群在老年衰弱中的研究进展,为老年衰弱的发病机制提供依据。

Frailty,a common geriatric syndrome,is a serious problem in healthy aging.However,its pathogenesis remains unclear.It is a general agreement that frailty is caused by multiple factors,in which immune dysfunction and chronic inflammation play an important role.Because gut microbiota is associated with immune function and chronic inflammation,the correlation between gut microbiota and frailty has drawn increasing attention in recent years.This article mainly introduced the progress in the research of gut microbiota in the frail elderly,providing the reference for the pathogenesis of frailty.