环状RNA在慢性阻塞性肺疾病中生物学作用的研究进展

Research progress of biological roles of circRNAs in chronic obstructive pulmonary disease

环状RNA(circRNA)是一类新型的非编码RNA,由于其环状结构稳定存在于各种生物体中并参与代谢调节功能,环状RNA参与多种疾病的发生与发展,且与多种呼吸系统疾病密切相关。慢性阻塞性肺疾病是一种基因与环境共同作用的复杂呼吸系统疾病,有研究发现环状RNA在慢性阻塞性肺疾病发病中起重要作用,且可能成为慢性阻塞性肺疾病诊断标志物或新的治疗干预靶点。本文将环状RNA与慢性阻塞性肺疾病发生机制的关系进行综述,总结环状RNA在慢性阻塞性肺疾病中的生物学作用。

circRNA is a new type of non-coding RNA.Due to its stable circular structure in various organisms and its involvement in metabolic regulation of organisms,circRNA is involved in the occurrence and development of a variety of diseases and is closely related to a variety of respiratory diseases.Chronic obstructive pulmonary disease(COPD)is a complex respiratory disease associated with gene and environment.Some studies have found that circRNAs play an important role in the pathogenesis of COPD and may become a diagnostic marker or a new therapeutic intervention target for COPD.The correlation between circRNAs and the pathogenesis mechanism of chronic obstructive pulmonary disease is reviewed to summarize the biological role of circRNAs in chronic obstructive pulmonary disease.