支气管哮喘患儿治疗前后BNP、PCT及IL-6检测的临床意义

Clinical significance of detection of BNP,PCT and IL-6 before and after treatment in children with bronchial asthma

目的探讨支气管哮喘患儿治疗前后血浆B型脑钠肽(BNP)、降钙素原(PCT)及白细胞介素-6(IL-6)检测的临床意义。方法选取2019年2月至2021年1月简阳市人民医院收治的152例小儿支气管哮喘患者为研究组,选取同期139例健康体检儿童为对照组。比较研究组治疗前后与对照组BNP、PCT及IL-6水平;比较支气管哮喘患者治疗前后肺功能包括第1秒用力呼气容积占预计值百分比(FEV1)、呼气峰值流速占预计值百分比(PEF)、1秒用力呼气容积占用力肺活量的百分比(FEV1/FVC);分析支气管哮喘患者BNP、PCT及IL-6水平与肺功能指标的相关性。结果BNP、PCT及IL-6水平:研究组治疗前>研究组治疗后>对照组,差异有统计学意义(P<0.05)。支气管哮喘患者治疗前FVC1、PEF、FEV1/FVC明显低于治疗后,差异均具有统计学意义(P<0.05)。支气管哮喘患者BNP、PCT及IL-6水平与FVC1、PEF、FEV1/FVC值呈负相关关系(P<0.05)。结论临床可通过检测支气管哮喘患者BNP、PCT及IL-6水平的变化了解患者的病情变化及进行预后判断。

Objective To investigate the clinical significance of plasma B-type brain natriuretic peptide(BNP),procalcitonin(PCT)and interleukin-6(IL-6)test before and after treatment in children with bronchial asthma.Methods A total of 152 pediatric bronchial asthma patients admitted to Jianyang People’s Hospital from February 2019 to January 2021 were selected as the study group;139 healthy children during the same time period were selected as the control group.Compared the levels of BNP,PCT and IL-6 in the study group before and after treatment with those in the control group;compared lung function in patients with bronchial asthma before and after treatment,including forced expiratory volume in one second(FEV1),peak expiratory flow rate as a percentage of expected value(PEF),the percentage of forced vital capacity occupied by the forced expiratory volume in 1 second(FEV1/FVC);analyzed the correlation between BNP,PCT and IL-6 levels and lung function indexes in patients with bronchial asthma.Results BNP,PCT and IL-6 levels:before treatment in the study group>after treatment in the study group and the control group,the difference was statistically significant(P<0.05).FVC1,PEF,FEV1/FVC before treatment in patients with bronchial asthma were significantly lower than after treatment,and the difference was statistically significant(P<0.05).The levels of BNP,PCT and IL-6 in patients with bronchial asthma were negatively correlated with the values of FVC1,PEF,FEV1/FVC(P<0.05).Conclusion Clinically,the changes in BNP,PCT and IL-6 levels in patients with bronchial asthma can be used to understand the changes in the patient’s condition and judge the prognosis.