Ki-67、nm23和PTEN在CMM中的表达及与淋巴结转移的关系

The relationship between the expression of Ki-67,nm23 and PTEN in CMM and lymph node metastasis

目的探讨Ki-67、肿瘤转移抑制基因23(nm23)和第10号染色体同源丢失性磷酸酶-张力蛋白基因(PTEN)在皮肤黑色素瘤(CMM)中的表达及与淋巴结转移的关系。方法选取2017年1月至2020年1月河南省驻马店市中心医院收治的207例CMM患者,将病灶标本设为研究组,并选取距癌组织3 cm处的癌旁组织作为对照组。比较两组Ki-67、nm23和PTEN的表达水平,分析影响CMM患者淋巴结转移的单因素、多因素。结果研究组Ki-67的阳性表达高于对照组,nm23、PTEN阳性表达低于对照组,差异均有统计学意义(P<0.05)。转移组Ki-673、nm2、PTEN阳性表达低于未转移组,差异有统计学意义(P<0.05)。年龄、性别、吸烟等为非影响患者淋巴结转移的因素(P>0.05),临床分期、Ki-67、nm23及PTEN为影响患者淋巴结转移的单因素(P<0.05)。多因素Logistic回归模型分析结果显示,临床分期、Ki-67、nm23和PTEN为影响患者淋巴结转移的独立危险因素(P<0.05)。结果Ki-67、nm23和PTEN在CMM患者中的表达水平存在差异,通过检测其水平能为临床预后及治疗提供新的思路与依据。

Objective To investigate the relationship between the expression of Ki-67,tumor nonmetastasis23(nm23)antigen and phosphate and tension homology deleted on chromsome ten(PTEN)in cutaneous malignant melanoma(CMM)and lymph node metastasis.Methods The clinical data of 207 CMM patients admitted to Zhumadian Central Hospital in Henan Province from January 2017 to January 2020 were selected.And the lesion specimens were set as the study group,and normal tissues 3 cm away from the cancer tissue were selected as the control group.The expression levels of Ki-67,nm23 and PTEN were compared between the two groups,and the single and multiple factors affecting lymph node metastasis of CMM patients were analyzed.Results The positive expression of Ki-67 in the study group was higher than that in the control group,but the positive expressions of nm23 and PTEN in the study group was lower than those in the control group,and the difference was statistically significant(P<0.05).The positive expressions of Ki-67,nm2,PTEN in the metastasis group were lower than those in the non-metastasis group,and the difference was statistically significant(P<0.05).Age,gender,smoking,etc.were non-influencing factors of lymph node metastasis(P>0.05),while clinical stage,Ki-67,nm23 and PTEN were the single factors affecting lymph node metastasis(P<0.05).Multivariate Logistic regression model analysis showed that clinical stage,Ki-67,nm23 and PTEN were independent risk factors for lymph node metastasis(P<0.05).Conclusion There are differences in the expression levels of Ki-67,nm23 and PTEN in CMM patients,and the detection of their levels can provide new ideas and basis for clinical prognosis and treatment.