寻常型银屑病患者VEGF、IFN-y和S100A12的表达及与疾病活动性的相关性

Expression of VEGF,IFN-y and S100A12 in patients with psoriasis vulgaris and their correlation with disease activity

目的分析寻常型银屑病患者血管内皮生长因子(VEGF)、干扰素-y(IFN-y)和S100A12的表达及与疾病活动性的相关性。方法选取2019年8月至2020年8月航空总医院收治的88例寻常型银屑病患者设为观察组,其中进行期31例,静止期28例,退行期29例,根据患者病情严重程度按照银屑病皮损面积及严重程度指数(PASI)积分法分为:轻度(<10分)36例、中重度(≥10分)52例。选取85例同期在本院行健康体检者作为对照组。比较不同人群中VEGF、IFN-y和S100A12的表达水平,并分析VEGF、IFN-y和S100A12与疾病活动性的相关性。结果观察组中VEGF、IFN-y和S100A12的表达水平明显高于对照组,差异有统计学意义(P<0.05)。轻度组中VEGF、IFN-y及S100A12表达水平明显低于中重度组,差异有统计学意义(P<0.05)。不同时期寻常型银屑病患者VEGF、IFN-y和S100A12的表达水平:进行期>静止期>退行期,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,VEGF、IFN-y和S100A12与PASI评分均为正相关(r=0.511,r=0.675,r=0.431,P均<0.05)。结论VEGF、IFN-y和S100A12与寻常型银屑病发生、发展密切相关,监测三者水平变化可评估患者疾病严重程度。

Objective To analyze the expression of vascular endothelial growth factor(VEGF),Interferon-y(IFN-y)and S100 A12 in patients with psoriasis vulgaris and their correlation with disease activity.Methods The 88 patients with psoriasis vulgaris admitted to our hospital from August 2019 to August 2020 were selected as the observation group,of which 31 patients were in the progressive stage,28 patients were in the stationary stage,and 29 patients were in the degenerative stage.According to the disease activity of the patients,the Psoriasis area and severity index(PASI)integration method,they were divided into:mild group(<10 points)36 cases,moderate-severe group(≥10 points)52 cases.The expression levels of VEGF,IFN-y and S100 A12 in different groups were compared,and the correlation between levels of VEGF,IFN-y and S100 A12 and disease activity was analyzed.Results The expression levels of VEGF,IFN-y and S100 A12 in the observation group were significantly higher than those in the control group(P<0.05).The expression levels of VEGF,IFN-y and S100 A12 in the mild group were significantly lower than those in the moderate-severe group(P<0.05).There were differences in the expression levels of VEGF,IFN-y and S100 A12 in patients with psoriasis vulgaris at different stage(P<0.05).The levels of VEGF,IFN-y and S100 A12 were the highest in patients at the progressive stage,and were the lowest at the degenerative stage.The expression levels of VEGF,IFN-y and S100 A12 in patients with psoriasis vulgaris in different periods:progressive stage>stationary stage>degenerative stage,the difference was statistically significant(P<0.05).Pearson correlation analysis results showed that VEGF,IFN-y and S100 A12 were positively correlated with PASI scores(r=0.511,r=0.675,r=0.431,all P<0.05).Conclusion VEGF,IFN-y and S100 A12 are closely related to the occurrence and development of psoriasis vulgaris.Monitoring the changes in the three levels can evaluate the severity of the disease.