NLR、PLR对结肠癌根治术后手术部位感染的预测价值

Predictive value of NLR and PLR for surgical site infection after radical resection of colon cancer

目的观察中性粒细胞淋巴细胞比值(NLR)、血小板淋巴细胞比值(PLR)对结肠癌根治术后手术部位感染(SSI)的预测价值。方法选取2018年1月至2021年1月首都医科大学附属北京世纪坛医院收治的96例结肠癌根治术患者,将术后发生SSI的19例患者纳入感染组,余77例纳入未感染组,观察两组患者术前基线实验室检查资料,比较两组患者NLR、PLR水平,采用logistics回归分析影响患者发生SSI的危险因素,采用ROC曲线分析术前NLR、PLR对结肠癌根治术后SSI的预测价值。结果感染组患者NLR、PLR水平高于未感染组,差异有统计学意义(P<0.05)。两组患者中性粒细胞计数(NEUT)、淋巴细胞计数(TLC)、血小板计数(PLT)、血红蛋白(HB)水平比较差异无统计学意义(P>0.05)。logistics回归分析显示,NLR、PLR水平均是影响结肠癌术后SSI发生的影响因素(P<0.05)。ROC曲线分析显示,术前NLR、PLR水平用于评估结肠癌根治术后SSI患者诊断价值的AUC分别为0.722、0.681。结论NLR、PLR水平与结肠癌根治术后SSI发生密切相关,术前重视其水平对结肠癌根治术后SSI的发生具有一定的预测价值。

Objective To observe the predictive value of neutrophil lymphocyte ratio(NLR)and platelet lymphocyte ratio(PLR)for surgical site infection(SSI)after radical resection of colon cancer.Methods 96 patients undergoing radical resection of colon cancer admitted to Beijing Shijitan Hospital,Capital Medical University were selected from January 2018 to January 2021.19 cases with postoperative SSI were included in the infected group,and the remaining 77 cases were enrolled as the non-infected group.Preoperative baseline laboratory examination data were observed in the two groups of patients,and the levels of NLR and PLR were compared between the two groups.Logistics regression analysis was used to analyze the risk factors affecting patients with SSI,and the ROC curve was applied to analyze the predictive value of preoperative NLR and PLR on SSI after radical resection of colon cancer.Results The levels of NLR and PLR in the infected group were higher than those in the non-infected group(P<0.05).There were no statistically significant differences in the levels of neutrophil count(NEUT),lymphocyte count(TLC),platelet count(PLT)and hemoglobin(HB)between the two groups(P>0.05).Logistics regression analysis showed that NLR and PLR were the influencing factors for SSI after colon cancer surgery(P<0.05).ROC curve analysis showed that the AUC values of preoperative NLR and PLR in assessing diagnostic value on SSI after radical resection of colon cancer were 0.722 and 0.681 respectively.Conclusion The levels of NLR and PLR are closely related to the occurrence of SSI after radical resection of colon cancer.Preoperative attention to their levels has certain predictive value on the occurrence of SSI after radical resection of colon cancer.