Gal-3、BNP及LVEF在心力衰竭患者中的变化及临床意义

Changes and clinical significance of galectin-3,B-type natriuretic peptide and left ventricular ejection fraction in patients with heart failure

目的分析半乳糖凝集素-3(Gal-3)、B型钠尿肽(BNP)及左室射血分数(LVEF)在心力衰竭患者中的变化及临床意义。方法选取2017年3月至2020年3月北京核工业医院收治的102例心力衰竭患者设为研究组,另选取同期91例行心功能检查的健康体检者作为健康组。比较两组以及不同NYHA心功能分级心力衰竭患者的Gal-3、BNP及LVEF水平,分析影响心力衰竭患者预后的单因素、多因素。结果研究组Gal-3、BNP水平明显高于健康组,LVEF低于健康组,差异具有统计学意义(P<0.05)。Gal-3、BNP水平:Ⅱ级<Ⅲ级<Ⅳ级,LVEF值:Ⅱ级>Ⅲ级>Ⅳ级,差异有统计学意义(P<0.05)。年龄、性别、心率、高血压等非影响心力衰竭患者预后的单因素(P>0.05),心功能分级、Gal-3、BNP及LVEF为影响心力衰竭患者预后的单因素(P<0.05)。多因素Logistic回归模型分析结果显示,心功能分级、Gal-3、BNP及LVEF为影响心力衰竭患者预后的独立危险因素(P<0.05)。结论Gal-3、BNP、LVEF作为影响心力衰竭预后的因素,其在不同级别心力衰竭中有着不同表达,临床可根据其水平变化作为心力衰竭的诊断和预后判断的参考依据。

Objective To analyze the changes and clinical significance of galectin-3(Gal-3),B-type natriuretic peptide(BNP)and left ventricular ejection fraction(LVEF)in patients with heart failure.Methods The clinical data of 102 patients with heart failure treated in this hospital from March 2017 to March2020 were collected and set as the study group.Another 91 patients who had a physical examination of cardiac function at the same period were selected as the healthy group.The Gal-3,BNP and LVEF between the two groups and the Gal-3,BNP and LVEF of patients with different grading in NYHA cardiac function were compared.At the same time,single and multiple factors affecting the prognosis of patients with heart failure were analyzed.Results The Gal-3 and BNP levels in the study group were significantly higher than those in the healthy group,while the LVEF was lower than that in the healthy group.The difference was statistically significant(P<0.05).The higher the level of cardiac function was,the higher the levels of Gal-3 and BNP were,and the lower the LVEF value was,the difference is statistically significant(P<0.05).Age,gender,heart rate,hypertension and other factors did not affect the prognosis of patients with heart failure(P>0.05),while cardiac function class,Gal-3,BNP and LVEF were the single factors affecting the prognosis of patients with heart failure(P<0.05).The results of multivariate logistic regression model analysis showed that the classification of heart function,Gal-3,BNP and LVEF were independent risk factors affecting the prognosis of patients with heart failure(P<0.05).Conclusion Gal-3,BNP,and LVEF are factors that affect the prognosis of heart failure,and they have different expressions in different grades of heart failure.Clinically,the changes in their levels can be used as a reference for the diagnosis and prognosis of heart failure.