右美托咪定口服与滴鼻在小儿包皮环切术麻醉中的应用分析

Application analysis of oral and intranasal application of dexmedetomidine in anesthesia of circumcision in children

目的 观察右美托咪定口服与滴鼻在小儿包皮环切术麻醉中的应用效果。方法 100例行小儿包皮环切术患儿,采用随机数字表法分为研究组与对照组,各50例。研究组术前30 min口服右美托咪定,对照组术前30 min滴鼻右美托咪定。比较两组给药过程合作率、麻醉后监测治疗室(PACU)停留时间、Funk神经行为评分、术中及术后不良反应发生情况。结果 研究组合作率94%高于对照组的6%,差异有统计学意义(P<0.05)。研究组PACU停留时间为(44.2±10.1)min,对照组PACU停留时间为(43.5±9.6)min,两组PACU停留时间比较,差异无统计学意义(P>0.05)。研究组与父母分离、静脉穿刺时Funk神经行为评分分别为(3.2±0.4)、(3.6±0.6)分;对照组分别为(3.4±0.5)、(3.5±0.5)分。两组与父母分离、静脉穿刺时Funk神经行为评分比较,差异无统计学意义(P>0.05)。两组均无患儿发生呼吸抑制、心动过缓、术后恶心呕吐、躁动。结论 术前30 min口服右美托咪定2.5μg/kg用于小儿基础麻醉更易被患儿及家长接受,并不增加术后患儿苏醒期不良症状的发生。

Objective To observe the application effect of oral and intranasal application of dexmedetomidine in anesthesia of circumcision in children.Methods A total of 100 children undergoing circumcision were divided into research group and control group by random numerical table,with 50 cases in each group.The research group took dexmedetomidine orally 30 min before the surgery,and the control group took dexmedetomidine intranasally 30 min before the surgery.The cooperation rate during administration,stay time in the post-anaesthesia care-unit(PACU),Funk neurobehavioral score,intraoperative and occurrence of postoperative adverse reactions were compared between the two groups.Results The cooperation rate 94%of the research group was higher than 6%of the control group,and the difference was statistically significant(P<0.05).The PACU stay time in the research group was(44.2±10.1)min,and the PACU stay time in the control group was(43.5±9.6)min.There was no statistically significant difference in PACU stay time between the two groups(P>0.05).The Funk neurobehavioral scores at separation from parents and venipuncture in the research group were(3.2±0.4)and(3.6±0.6)points,and those in the control group were(3.4±0.5)and(3.5±0.5)points.There was no statistically significant difference in Funk neurobehavioral scores between the two groups at separated from their parents and venipuncture(P>0.05).No children in the two groups experienced respiratory depression,bradycardia,postoperative nausea,vomiting,or restlessness.Conclusion Oral application of dexmedetomidine 2.5μg/kg for pediatric anesthesia is more acceptable to the children and parents,and does not increase the incidence of adverse symptoms during recovery after the surgery.