莫西沙星联合头孢哌酮钠舒巴坦钠治疗老年重症肺炎的临床效果

Clinical efficacy of moxifloxacin combined with cefoperazone sodium and sulbactam sodium in the treatment of severe pneumonia in the elderly

目的研究莫西沙星(Mfx)联合头孢哌酮钠舒巴坦钠(TZP)治疗老年重症肺炎的临床治疗效果。方法选取2019年2月至2020年8月辽宁省健康产业集团铁煤总医院收治的72例老年重症肺炎患者作为研究对象,根据治疗方法分为观察组和对照组,每组各36例。观察组采用TZP联合Mfx进行治疗,对照组采用TZP疗法,比较两组临床疗效、不良反应及症状恢复时间。结果观察组总有效率为94.45%,高于对照组的77.77%,差异有统计学意义(P<0.05);两组不良反应率比较,差异无统计学意义(P>0.05);观察组体温、痰液颜色、WBC计数恢复正常时间分别为(3.05±0.82)d、(5.25±1.12)d、(4.01±0.78)d,低于对照组的(4.56±0.88)d、(6.90±1.75)d、(5.96±1.21)d,差异有统计学意义(P<0.05)。结论Mfx联合TZP治疗老年重症肺炎,可缩短症状恢复正常时间,安全性较高。

Objective To investigate the clinical efficacy of moxifloxacin(Mfx)combined with cefoperazone sodium and sulbactam sodium(TZP)in the treatment of severe pneumonia in the elderly.Methods A total of 72 elderly patients with severe pneumonia admitted to and treated in our hospital from February 2019 to August 2020 were selected as the research objects,and they were divided into the observation group(n=36)and the control group(n=36)according to treatment methods.The observation group was treated with TZP combined with Mfx,while the control group was treated with TZP.The clinical efficacy,adverse reactions(ARs)and symptom recovery time of the two groups were compared.Results The total effective rate of the observation group was 94.45%,which was higher than 77.77%of the control group.The difference was statistically significant(P<0.05);the difference in adverse reaction rates between the two groups was not statistically significant(P>0.05);the recovery time of sputum color and WBC count to normal was(3.05±0.82)d,(5.25±1.12)d,(4.01±0.78)d,respectively,which was lower than(4.56±0.88)d and(6.90±1.75)d,(5.96±1.21)d of control group,the difference was statistically significant(P<0.05).Conclusion Mfx combined with TZP in the treatment of elderly patients with severe pneumonia can shorten the time for symptoms to return to normal,which has higher safety.