浙江省某地区生活饮用水中44种典型药物活性成分污染水平调查

Investigation on the contamination of 44 pharmaceutically active compounds in drinking water in an area of Zhejiang Province

目的对浙江省某地区生活饮用水中44种典型药物活性成分污染水平进行调查。方法采用超高效液相色谱-串联三重四级杆质谱法对水源水、出厂水和末梢水中44种典型药物活性成分的污染水平和污染特征进行调查,应用多重线性回归进行统计学意义分析。结果饮用水水源水、出厂水、末梢水中,检出28种药物活性成分,大多数药物活性成分的污染水平为水源水>出厂水>末梢水。金刚烷胺的检出率最高,总检出率为66.9%。枯水期和丰水期的检出率分别为91.4%、32.8%,检出浓度最大值为347.7 ng/L和4.910 ng/L。此外,强力霉素和罗红霉素在枯水期和丰水期的检出率均超过18%。剩余的药物活性成分中,大部分药物在枯水期的检出率和检出浓度均大于丰水期。结论浙江省某地区生活饮用水源中44种典型药物活性成分污染水平总体不高,但金刚烷胺、强力霉素和罗红霉素的污染情况相对较严重,应引起足够的重视。

Objective To investigate the pollution status of 44 pharmaceutically active compounds in drinking water in an area of Zhejiang Province.Methods The pollution levels and characteristics of 44 typical pharmaceutically active compounds in the samples of raw water,treated water and tap water in an area of Zhejiang were conducted by ultra-high performance liquid chromatography coupled with triple quadrupole mass spectrometry.Statistical significance was analyzed by multiple linear regression.Results Twenty-eight active pharmaceutical ingredients were detected in the raw water,treated water,tape water samples.Raw water samples were polluted most significantly,followed by treated water and tap water samples.Amantidine was detected most frequently in all water samples,with a total detection rate of nearly 66.9%.The detection rates in dry season and wet season were 91.4% and 32.8%,respectively,and the maximum detected concentrations were 347.7 ng/L and 4.910 ng/L.In addition,the detection rates of doxycycline and roxithromycin were more than 18% in dry and wet seasons.The detection rate and concentration of most of the remaining active ingredients were higher in dry season than in wet season.Conclusion The overall pollution level of 44 pharmaceutically active components in drinking water in the area of Zhejiang is not high,but the pollution status of amantidine,doxycycline and roxithromycin is relatively serious,which should be drawn attention to.