低密度脂蛋白受体对三阴性乳腺癌患者预后的影响

Effect of low-density lipoprotein receptor on prognosis of patients with triple-negative breast cancer

目的探讨低密度脂蛋白受体(LDLR)对三阴性乳腺癌患者预后的影响。方法回顾性分析山东第一医科大学附属省立医院2010年1月至2016年12月收治的107例三阴性乳腺癌患者和136例乳腺良性肿瘤患者的临床资料。收集三阴性乳腺癌患者的病理组织和癌旁正常乳腺组织,以及乳腺良性肿瘤患者的病理组织,采用免疫组织化学法检查各组织中的LDLR表达情况,比较不同组织的LDLR得分,分析三阴性乳腺癌患者无病生存和总生存的危险因素。结果三阴性乳腺癌组织LDLR得分高于乳腺良性肿瘤组织和三阴性乳腺癌的癌旁组织[3(2,8)分比3(3,4)、3(0,4)分],且乳腺良性肿瘤组织LDLR得分高于三阴性乳腺癌的癌旁组织(均P<0.001)。多因素回归分析结果显示,LDLR得分和淋巴结转移为三阴性乳腺癌无病生存的独立影响因素(比值比=0.536、2.624,95%置信区间:0.295~0.974、1.397~4.930,均P<0.05),淋巴结转移是影响三阴性乳腺癌总生存的独立危险因素(比值比=5.268,95%置信区间:2.412~11.506,P<0.001)。结论三阴性乳腺癌组织LDLR得分高于乳腺良性肿瘤组织和三阴性乳腺癌的癌旁组织。LDLR得分和淋巴结转移为三阴性乳腺癌患者无病生存的独立影响因素,检测LDLR有助于预测三阴性乳腺癌患者的无病生存期。

Objective To investigate the effect of low-density lipoprotein receptor(LDLR)on the prognosis of patients with triple-negative breast cancer.Methods The clinical data of 107 patients with triple-negative breast cancer and 136 patients with benign breast tumor admitted to Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2010 to December 2016 were retrospectively analyzed.The pathological tissues and adjacent normal breast tissues of patients with triple-negative breast cancer and pathological tissues of patients with benign breast tumor were collected.The expression of LDLR in each tissue was examined by immunohistochemistry.The LDLR score of different tissues was compared,and the risk factors for disease-free survival and overall survival were analyzed in patients with triple-negative breast cancer.Results The LDLR score of triple-negative breast cancer tissues was higher than that of benign breast tumor tissues and triple-negative breast cancer adjacent tissues[3(2,8)vs 3(3,4),3(0,4)],and LDLR score of benign breast tumor was higher than that of triple-negative breast cancer adjacent tissues(all P<0.001).Multivariate regression analysis showed that LDLR score and lymph node metastasis were independent factors affecting the disease-free survival of triple-negative breast cancer(odds ratio=0.536 and 2.624,95%confidence interval:0.295-0.974 and 1.397-4.930,both P<0.05).Lymph node metastasis was an independent risk factor affecting the overall survival of triple-negative breast cancer(odds ratio=5.268,95%confidence interval:2.412-11.506,P<0.001).Conclusions The LDLR score of triple-negative breast cancer tissues is higher than that of benign breast tumor tissues and triple-negative breast cancer adjacent tissues.LDLR score and lymph node metastasis are independent factors affecting the disease-free survival of patients with triple-negative breast cancer.Detection of LDLR is helpful to predict the disease-free survival of patients with triple-negative breast cancer.