慢性阻塞性肺疾病蒙医证型与临床指标的相关性研究

Correlation between Mongolian medicine syndrome type and clinical index of chronic obstructive pulmonary disease

目的探究慢性阻塞性肺疾病(COPD)蒙医辨证分型与临床指标的相关性。方法选取2020年1月至2021年3月内蒙古自治区人民医院蒙医科、呼吸科住院部和门诊部收治的COPD稳定期患者86例。进行蒙医辨证分型,记录患者年龄、性别、病程等一般资料,并检测其肺功能、血气分析、6 min步行试验距离等临床指标的水平,分析蒙医证型与临床指标的相关性。结果86例患者中,蒙医证型为赫依型者41例(47.7%),巴达干型者27例(31.4%),协日型者18例(20.9%),证型分布差异有统计学意义(χ;=14.058,P=0.001)。不同证型COPD患者的性别比例比较差异无统计学意义(P=0.411);赫依型患者发病年龄明显大于巴达干型[(66±6)岁比(60±7)岁],差异有统计学意义(P=0.003);巴达干型患者病程明显长于赫依型和协日型患者[(13.2±4.0)年比(6.6±2.7)、(6.2±2.4)年],差异均有统计学意义(均P<0.05)。不同证型COPD患者第1秒用力呼气容积(FEV;)、FEV;占预计值百分比、FEV;与用力肺活量比值比较差异均无统计学意义(均P>0.05)。各证型患者动脉血氧分压从高到低分别是巴达干型、赫依型、协日型,动脉血二氧化碳分压从高到低分别是协日型、赫依型、巴达干型,动脉血氧饱和度从高到低分别是巴达干型、赫依型、协日型,pH值从高到低分别是赫依型、巴达干型、协日型,3组间比较差异均有统计学意义(均P<0.05)。各证型患者6 min步行试验距离组间差异无统计学意义(F=0.332,P=0.718)。结论COPD蒙医证型可能与患者年龄、病程、血气分析等临床指标有密切的相关性。

Objective To explore the correlation between Mongolian medicine syndrome type and clinical index of chronic obstructive pulmonary disease(COPD).Methods From January 2020 to March 2021,86 patients with stable COPD were selected from Department of Mongolian Medicine,Department of Respiratory and Department of Outpatient,Inner Mongolia Autonomous Region People′s Hospital.Mongolian medicine syndrome differentiation was carried out,the general data such as age,gender and course of disease were recorded,and the levels of pulmonary function,blood gas analysis,6 min walking test distance and other clinical indexes were measured.The correlation between Mongolian medicine syndrome type and clinical index was analyzed.Results Among the 86 patients,41 cases(47.7%)of Hay type,27 cases(31.4%)of Badakan type and 18 cases(20.9%)of Cohida type according to Mongolian medical syndrome type;there was significant difference in the distribution of syndrome types(χ;=14.058,P=0.001).There was no significant difference in the gender ratio of patients with different syndrome types(P=0.411).The onset age of patients with Hay type was significantly higher than that of patients with Badakan type[(66±6)years vs(60±7)years],and the difference was statistically significant(P=0.003).The course of disease in patients with Badakan type was significantly longer than that in patients with Hay type and Cohida type[(13.2±4.0)years vs(6.6±2.7),(6.2±2.4)years],and the difference was statistically significant(both P<0.05).There were no significant differences in the first second forced expiratory volume(FEV;),the percentage of FEV;in the predicted value,and the ratio of FEV;to forced vital capacity among COPD patients with different syndrome types(all P>0.05).Arterial oxygen partial pressure in descending order was Badakan type,Hay type and Cohida type,arterial carbon dioxide partial pressure in descending order was Cohida type,Hay type and Badakan type,arterial oxygen saturation in descending order was Badakan type,Hay type and Cohida type,pH value in descending order was Hay type,Badakan type and Cohida type,respectively,and there were significant differences among the three groups(all P<0.05).There was no significant difference in 6 min walking test distance among the three groups(F=0.332,P=0.718).Conclusion The Mongolian medicine syndrome type of COPD may be closely related to age,course of disease,blood gas analysis and other clinical indicators.