不同EB病毒DNA载量的传染性单核细胞增多症患儿临床特征分析

Clinical characteristics of infectious mononucleosis children with different Epstein-Barr virus DNA loads

目的:研究传染性单核细胞增多症(IM)患儿血EB病毒脱氧核糖核苷酸载量与其临床症状的关联。方法:选取28例患有传染性单核细胞增多症患儿的临床资料,根据血EB病毒(EBV)脱氧核糖核苷酸载量数据,将其分为高载量组(16例)、低载量组(12例),前者载量≥5.0×10^(3)copies/mL,后者<5.0×10^(3) copies/mL。比较2组患儿临床症状及实验室指标,并分析IM患儿EB病毒载量与临床特征的相关性。结果:相比低载量组,高载量组患儿发热时长更久,更易发生脾脏肿胀,且颈部淋巴结最大直径也更大(P<0.05);高载量组患儿淋巴细胞计数(LN)、乳酸脱氢酶(LDH)水平、EB病毒衣壳抗原IgM抗体(EBV-VCA-IgM)数值高于低载量组(P<0.05);血EB病毒的脱氧核糖核苷酸载量与热程\淋巴结最大直径、LN、LDH、VCA-IgM均呈正相关。结论:患儿IM的EBV脱氧核糖核苷酸载量与临床特征存在关联。

Objective:To study the relationship between blood EB virus deoxyribonucleotide load and clinical symptoms in patients with infectious mononucleosis(IM).Methods:Clinical data of 28 children with infectious mononucleosis was studied.Referring to the blood EB virus(EBV)deoxyribonucleotide load data,they were divided into high and low virus load groups,and the load of the former was not less than 5.0×10^(3)copies/ml,and the latter less than 5.0×10^(3) copies/ml.Clinical symptoms and laboratory indexes of the two groups of patients were compared.The correlation between EB virus DNA loads of the IM patients and clinical symptoms was analyzed.Results:Compared with the low load group,the patients in the high load group had longer fever time,were more likely to have spleen swelling,and the maximum diameter of cervical lymph nodes was larger(P<0.05).Compared with the low load group,the lymphocyte count(LN),lactate dehydrogenase(LDH)level and EBV-VCA-IgM value of patients in the high load group were higher(P<0.05).The logarithm of deoxyribonucleotide load of blood EB virus was directly proportional to the levels of splenomegaly,lymphocyte count,aspartate aminotransferase and lactate dehydrogenase.Conclusion:There is a correlation between EBV deoxyribonucleotide load and clinical characteristics in children with IM.